Synthesis and catalytical activity of new chiral 2-substituted pyrrole derivatives of alpha-amino acids and beta-amino alcohols

Gerçek Arkın, Zuhal


Synthesis of n-(2-propylphenyl) substituted chiral amino alcohols and their usage in enantioselective diethylzinc addition reactions
Günler, Zeynep İnci; Tanyeli, Cihangir; Department of Chemistry (2011)
IChiral 1,2-amino alcohols were synthesized via newly developed “intramolecular unsaturation transfer” using cyclohexanone, propargyl bromide, and various chiral amino alcohols as starting components. These amino alcohols can be potential chiral ligands for many asymmetric transformation reactions. Therefore, their effectiveness as chiral ligands in diethylzinc addition to benzaldehyde and N-diphenylphosphinoyl imines were tested. Various parameters including temperature, solvent, ligand amount etc. were sc...
Synthesis of metal binding artificial amino acids
Eşan, Gözde; Özçubukçu, Salih; Department of Chemistry (2014)
A large variety of peptides with different physical and chemical properties can be acquired by using different amino acids. Through chemical peptide synthesis, utilizing unnatural synthetic amino acids beside 21 natural amino acids, divergent peptides can also be obtained easily. Specifically amino acid and peptide conjugates of metals have received considerable attention due to their important role in many biological processes with unique structural properties. Moreover, it is well known that some metal io...
Synthesis and characterization of lithium tetraborate and lithium triborate phosphors doped with metals and their thermoluminescence properties
Çelik, Muzaffer Gençay; Yılmaz, Ayşen; Department of Chemistry (2016)
The phenomenon of thermoluminescence (TL) has been interested in the measurement of radiation dose over the past few decades. Thermoluminescence property of a material can be used in surface acoustic wave apparatus, sensor sector and non-linear optics (LASER). Moreover, in dosimetry TL concept has been utilized. Thermoluminescence dosimetry is interested in the fields of environmental, personnel, and clinical radiation applications. In this thesis, dosimetric phosphors lithium tetraborate (Li2B4O7: LTB) [1]...
Analysis of koch fractal antennas
İrgin, Ümit; Birand, Mehmet Tuncay; Department of Electrical and Electronics Engineering (2009)
Fractal is a recursively-generated object describing a family of complex shapes that possess an inherent self-similarity in their geometrical structure. When used in antenna engineering, fractal geometries provide multi-band characteristics and lowering resonance frequencies by enhancing the space filling property. Moreover, utilizing fractal arrays, controlling side lobe-levels and radiation patterns can be realized. In this thesis, the performance of Koch curve as antenna is investigated. Since fractals a...
Synthesis of peptide inhibitors for matrix metalloproteinase-2 and angiotensin converting enzyme /
Çiftçi, Burçe; Özçubukçu, Salih; Özen, Can; Department of Biotechnology (2014)
Matrix Metalloproteinases (MMPs) are one of the enzyme families of proteases that have zinc atom in the active site and they are involved in the degradation and regeneration of extracellular matrix. Specifically, they play an important role in tumor formation, tissue invasion, angiogenesis, and tumor metastasis. Matrix metalloprotease-2 (MMP-2) is a member of gelatinase class of MMP family and it has high activity in progression of skin, prostate, bladder, breast, lung, and ovary cancer. To control this inc...
Citation Formats
Z. Gerçek Arkın, “Synthesis and catalytical activity of new chiral 2-substituted pyrrole derivatives of alpha-amino acids and beta-amino alcohols,” Ph.D. - Doctoral Program, Middle East Technical University, 2000.