HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1)

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2019-01-01

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Özgül, İbrahim
Erdem, Murat
Erson Bensan, Ayşe Elif

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Heterogeneous nuclear ribonucleoprotein (HNRNPA1) gene maps to chromosome 12, plus strand and has 13 exons and 12 introns. There are three reported transcripts due to the alternative splicing. HNRNPA1 is one of the most abundant and ubiquitously expressed nuclear proteins. HNRNPA1 is a member of RNA-binding protein family comprising of 20 members in humans (Dreyfuss, 1993; Pinol-Roma, Choi, Matunis, & Dreyfuss, 1988). HNRNPA1 has diverse roles in RNA splicing, telomere length maintenance, miRNA maturation and mRNA transport from nucleus to cytoplasm.

Subject Keywords

HNRNPA1, RNA-binding protein, RNA splicing, Telomere length maintenance, miRNA maturation, mRNA transport

URI

https://hdl.handle.net/11511/32764

Journal

Atlas of Genetics and Cytogenetics in Oncology and Haematology

DOI

https://doi.org/10.4267/2042/70455

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Department of Biology, Article

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HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 Erdem, Murat; Özgül, İbrahim; Erson Bensan, Ayşe Elif (2018-06-01) Heterogeneous nuclear ribonucleoprotein (HNRNPA1) gene maps to chromosome 12, plus strand and has 13 exons and 12 introns. There are three reported transcripts due to the alternative splicing. HNRNPA1 is one of the most abundant and ubiquitously expressed nuclear proteins. HNRNPA1 is a member of RNA-binding protein family comprising of 20 members in humans (Dreyfuss, 1993; Pinol-Roma, Choi, Matunis, & Dreyfuss, 1988). HNRNPA1 has diverse roles in RNA splicing, telomere length maintenance,...
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Enantioselective Friedel-Crafts alkylation of indole with nitroalkenes in the presence of bifunctional squaramide organocatalysts Dündar, Esra; Tanyeli, Cihangir (2021-01-01) A series of chiral bifunctional quinine and 2-aminoDMAP based squaramide organocatalysts are evaluated in Friedel-Crafts alkylation of indoles with nitroolefins. These 3-substituted indole derivatives are synthesized in the presence of sterically encumbered tert-butyl squaramide/quinine with high enantioselectivity (up to >99% ee) and moderate chemical yields (up to 80%) by representing as chiral precursors for very important biologically active molecules. Besides, this asymmetric transformation provides a ...
An Investigation of HNRNPA1 functions in breast cancer Özgül, İbrahim; Erson Bensan, Ayşe Elif; Department of Molecular Biology and Genetics (2019) Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is an RNA-binding protein with a broad range of functions including transcriptional and translational regulation of mRNAs, transport of mRNAs from the nucleus, alternative splicing, telomere maintenance, and miRNA processing. Among all, miRNA related functions of HNRNPA1 are the least understood. Hence, in this study, we aim to investigate potential miRNAs regulated by HNRNPA1.Using HNRNPA1-silenced MCF7 cells, we identified several notable miRNAs using N...

Citation Formats

İ. Özgül, M. Erdem, and A. E. Erson Bensan, “HNRNPA1 (Heterogeneous nuclear ribonucleoprotein A1),” Atlas of Genetics and Cytogenetics in Oncology and Haematology, pp. 137–142, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32764.