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Molecular mechanism of estrogen-estrogen receptor signaling.
Date
2016-12-05
Author
Yaşar, P
Ayaz, G
User, Sd
Güpür, G
Muyan, Mesut
Metadata
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17 beta-Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)alpha and ER beta that are encoded by distinct genes. Localized at the pen-membrane, mitochondria, and the nucleus of cells that are dependent on estrogen target tissues, the ERs share similar, as well as distinct, regulatory potentials. Different intracellular localizations of the ERs result in dynamically integrated and finely tuned E2 signaling cascades that orchestrate cellular growth, differentiation, and death. The deregulation of E2-ER signaling plays a critical role in the initiation and progression of target tissue malignancies. A better understanding of the complex regulatory mechanisms that underlie ER actions in response to E2 therefore holds a critical trajectory for the development of novel prognostic and therapeutic approaches with substantial impacts on the systemic management of target tissue diseases.
Subject Keywords
Estrogen
,
Estrogen receptor
,
Molecular mechanism
,
Signaling
,
Structure
URI
https://hdl.handle.net/11511/33369
Journal
Reproductive medicine and biology
DOI
https://doi.org/10.1002/rmb2.12006
Collections
Department of Biology, Article
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17β-estradiol (E2), the main circulating estrogen hormone, is involved in the physiological and pathophysiological regulation of various tissue notably mammary tissue functions. E2 is responsible for the cellular proliferation, differentiation and/or death in target tissue. The E2 effect is mediated by the nuclear receptors, estrogen receptor α and β, as ligand-dependent transcription factors. Upon binding of E2, ER is converted to an active form and regulates the expression of target genes primarily throug...
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P. Yaşar, G. Ayaz, S. User, G. Güpür, and M. Muyan, “Molecular mechanism of estrogen-estrogen receptor signaling.,”
Reproductive medicine and biology
, pp. 4–20, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/33369.