The design and synthesis of a photo-controlled, peptide-based potential drug carrier

Parlak Khalily, Melek
Özçubukçu, Salih
Our focus in this study is on the design and synthesis of a light-responsive peptide-based nanocarrier in order to develop effective and biocompatible drug delivery systems. The synthesized nanocarrier is basically composed of peptide amphiphiles comprising a micelle forming a Pro-Pro-Pro-Lys-Lys-Lys peptide sequence with an attached anthracene fluorophore Anthracene containing an inner core of the micelle can serve as a storage site for poorly water-soluble drugs. Moreover, anthracenes that come in close proximity with the formation of micellar structures can undergo photodimerization upon irradiation at 365 nm, which disrupts the micelle structures formed by the self-assembly of the peptide amphiphiles. Therefore, if a drug is encapsulated within the hydrophobic core of this peptidic carrier system, its release can be induced by the controlled exposure of the anthracene moiety to UV light.


An interlaboratory study as useful tool for proficiency testing of chemical oxygen demand measurements using solid substrates and liquid samples with high suspended solid content
Raposo, F.; de la Rubia, M. A.; Borja, R.; Alaiz, M.; Beltran, J.; Cavinato, C.; Clinckspoor, M.; Demirer, Göksel Niyazi; Diamadopoulos, E.; Helmreich, B.; Jenicek, P.; Marti, N.; Mendez, R.; Noguerol, J.; Pereira, F.; Picard, S.; Torrijos, M. (Elsevier BV, 2009-11-15)
In 2008, the first Proficiency Testing Scheme of Chemical Oxygen Demand (1(st) COD-PTADG) was conducted to assess the results obtained for different research groups whose field work is mainly anaerobic digestion. This study was performed using four samples, two solid samples as raw materials and two solid samples to prepare high concentration suspended solid solutions. Invitations were sent to a large number of laboratories, mainly to anaerobic digestion research groups. Finally, thirty labs from sixteen co...
Development of new synthetic methodologies for indole derivatives
Kılıklı, Ahmet Alper; Balcı, Metin; Department of Chemistry (2010)
Synthesizing nitrogen containing heterocyclic compounds is one of the leading research areas throughout the organic chemistry due to their significant activities on biological systems. Among the various biologically active molecules, indole derivatives are of prime importance on the grounds of their proven clinical roles. Objective of this study is to synthesize new indole derivatives those may contribute treatment of several diseases like their analogues via a recently developed synthetic methodology. Besi...
A conjugated gold nanoparticle-azacyanine off-on-off fluorescence probe for sensitive and selective detection of G-quadruplexes
Bilgen, Ecenaz; Forough, Mehrdad; Persil Çetinkol, Özgül (Elsevier BV, 2020-09-01)
G-quadruplex secondary structures have gained significant recognition due to the discovery of their involvement in regulation of gene expression and their association with many diseases such as cancer and neurological disorders. Consequently, the need for the recognition and characterization of G-quadruplex structures has increased considerably. Here, we present a rapid, facile and sensitive off-on-off in vitro platform for G-quadruplex detection, based on the gold nanoparticle-azacyanine5 (AuNP-Aza5) conju...
The development of the novel synthesis for conduritols
Cantekin, Seda; Balcı, Metin; Department of Chemistry (2006)
Conduritols have attracted a great deal of attention in recent years owing to biological activities exhibited by them and also their usefulness in the synthesis of other natural products and pharmaceuticals. Conduritols show interesting inhibitor activity for some glycosidases and serve as important intermediates in the synthesis of inositols. In this study, novel synthetic strategies leading to highly functionalized cyclohexene derivative containing an aromatic ring, namely phenyl-substituted conduritol wa...
From Homoconjugated Push-Pull Chromophores to Donor-Acceptor-Substituted Spiro Systems by Thermal Rearrangement
Dengiz, Çağatay; KATO, Shin-ichiro; ZALIBERA, Michal; CIAS, Pawel; SCHWEIZER, W. Bernd; BOUDON, Corinne; GISSELBRECHT, Jean-Paul; GESCHEIDT, Georg; DIEDERICH, Francois (Wiley, 2014-01-27)
Series of homoconjugated push-pull chromophores and donor-acceptor (D-A)-functionalized spiro compounds were synthesized, in which the electron-donating strength of the anilino donor groups was systematically varied. The structural and optoelectronic properties of the compounds were investigated by X-ray analysis, UV/Vis spectroscopy, electrochemistry, and computational analysis. The homoconjugated push-pull chromophores with a central bicyclo[4.2.0]octane scaffold were obtained in high yield by [2+2] cyclo...
Citation Formats
M. Parlak Khalily and S. Özçubukçu, “The design and synthesis of a photo-controlled, peptide-based potential drug carrier,” TURKISH JOURNAL OF CHEMISTRY, pp. 1136–1145, 2018, Accessed: 00, 2020. [Online]. Available: