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A critical review of the state of the art of solid-phase microextraction of complex matrices III. Bioanalytical and clinical applications
Date
2015-09-01
Author
Souza-Silva, Erica A.
Reyes-Garces, Nathaly
Gomez-Rios, German A.
Boyacı, Ezel
Bojko, Barbara
Pawliszyn, Janusz
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Part III of this review focuses on the state of the art of solid-phase microextraction (SPME) applied to bioanalytical and clinical analysis. We describe and discuss recent applications and new advances in terms of extraction phases and SPME configurations. Biocompatible coatings for the direct extraction of different analytes from urine, blood and tissues are perhaps the most promising approach in SPME. We present a review of the different calibration strategies commonly employed, and a discussion on the advantages and the disadvantages of SPME related to the analysis of these biological matrices. (C) 2015 Elsevier B.V. All rights reserved,
Subject Keywords
Bioanalytical and clinical analysis
,
Blood
,
Complex matrix
,
High throughput
,
Drug
,
In-vivo sampling
,
Metabolomics
,
Solid-phase microextraction
,
Tissue
,
Urine
URI
https://hdl.handle.net/11511/35556
Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
DOI
https://doi.org/10.1016/j.trac.2015.04.017
Collections
Department of Chemistry, Article