A critical review of the state of the art of solid-phase microextraction of complex matrices III. Bioanalytical and clinical applications

Date

2015-09-01

Author

Souza-Silva, Erica A.
Reyes-Garces, Nathaly
Gomez-Rios, German A.
Boyacı, Ezel
Bojko, Barbara
Pawliszyn, Janusz

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Part III of this review focuses on the state of the art of solid-phase microextraction (SPME) applied to bioanalytical and clinical analysis. We describe and discuss recent applications and new advances in terms of extraction phases and SPME configurations. Biocompatible coatings for the direct extraction of different analytes from urine, blood and tissues are perhaps the most promising approach in SPME. We present a review of the different calibration strategies commonly employed, and a discussion on the advantages and the disadvantages of SPME related to the analysis of these biological matrices. (C) 2015 Elsevier B.V. All rights reserved,

Subject Keywords

Bioanalytical and clinical analysis, Blood, Complex matrix, High throughput, Drug, In-vivo sampling, Metabolomics, Solid-phase microextraction, Tissue, Urine

URI

https://hdl.handle.net/11511/35556

Collections

Department of Chemistry, Article