Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities

Date

2010-05-01

Author

ŞENOL, FATMA SEZER
ERDOĞAN ORHAN, İLKAY
Celep, Ferhat
Kahraman, Ahmet
Doğan, Musa
Yilmaz, Guelderen
ŞENER, BİLGE

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In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100 mu g/ml using an ELISA microplate reader. The extracts were also screened for their scavenging effect against DPPH radical and iron-chelating capacity. Total phenol and total flavonoid contents of Salvia fruticosa were determined. Among the 165 Salvia extracts screened, only the dichloromethane extract of S. fruticosa showed inhibition towards AChE at 100 mu g/ml having 51.07% of inhibition, while only the dichloromethane and ethyl acetate extracts of Salvia cilicica had a notable iron-chelating capacity at 100 mu g/ml having 54.71% of chelating capacity. Most of the extracts showed remarkable scavenging effect against DPPH radical.

Subject Keywords

Food Science, Analytical Chemistry, General Medicine

URI

https://hdl.handle.net/11511/36123

Journal

FOOD CHEMISTRY

DOI

https://doi.org/10.1016/j.foodchem.2009.09.066

Collections

Department of Biology, Article

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Citation Formats

F. S. ŞENOL et al., “Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities,” FOOD CHEMISTRY, pp. 34–43, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36123.