Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities

Celep, Ferhat
Kahraman, Ahmet
Doğan, Musa
Yilmaz, Guelderen
In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100 mu g/ml using an ELISA microplate reader. The extracts were also screened for their scavenging effect against DPPH radical and iron-chelating capacity. Total phenol and total flavonoid contents of Salvia fruticosa were determined. Among the 165 Salvia extracts screened, only the dichloromethane extract of S. fruticosa showed inhibition towards AChE at 100 mu g/ml having 51.07% of inhibition, while only the dichloromethane and ethyl acetate extracts of Salvia cilicica had a notable iron-chelating capacity at 100 mu g/ml having 54.71% of chelating capacity. Most of the extracts showed remarkable scavenging effect against DPPH radical.


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TOYRAN AL OTAİBİ, NESLİHAN; Severcan, Feride; Severcan, Mete; TURAN, Belma (Elsevier BV, 2008-10-01)
The effects of selenium supplementation on apex and right ventricle myocardia of the rat heart were investigated using Fourier transform infrared (FTIR) spectroscopy by examining the changes in the frequency values of major absorptions arising from lipids and proteins. Cluster analysis was used to discriminate the selenium treated group from the control by utilizing two distinct spectral regions, belonging to absorptions arising from lipids and proteins, respectively. In addition, protein secondary structur...
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Botanical origin of the nectar predominantly affects the chemical composition of honey. Analytical techniques used for reliable honey authentication are mostly time consuming and expensive. Additionally, they cannot provide 100% efficiency in accurate authentication. Therefore, alternatives for the determination of floral origin of honey need to be developed. This study aims to discriminate characteristic Anatolian honey samples from different botanical origins based on the differences in their molecular co...
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Differential scanning calorimetry (DSC) was used to evaluate the relative high hydrostatic pressure (HHP) resistances of bacterial strains from Staphylococcus aureus and Escherichia coli O157:H7 in vivo. The total apparent enthalpy change and thermal stability were two DSC parameters used to compare bacterial strains of untreated control and pressure-treated bacteria. DSC thermograms indicated that ribosomal denaturation appears to be a major factor in cell death by both thermal and high pressure treatments...
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Aim of this study was to determine the extent of pollution in the West Black Sea Coast of Turkey by measuring CYP1A associated EROD activity, phase II enzyme, glutathione S-transferase and antioxidant enzymes, catalase and glutathione reductase activities and immunochemical detection of CYP1A protein level in the liver of mullet. The fish samples were caught from six locations having a varying degree of pollution in the West Black Sea Region of Turkey in August 2005, 2006 and 2007. Mullets caught from Zongu...
Citation Formats
F. S. ŞENOL et al., “Survey of 55 Turkish Salvia taxa for their acetylcholinesterase inhibitory and antioxidant activities,” FOOD CHEMISTRY, pp. 34–43, 2010, Accessed: 00, 2020. [Online]. Available: