Effects of selenium supplementation on rat heart apex and right ventricle myocardia by using FTIR spectroscopy: A cluster analysis and neural network approach

Severcan, Feride
Severcan, Mete
TURAN, Belma
The effects of selenium supplementation on apex and right ventricle myocardia of the rat heart were investigated using Fourier transform infrared (FTIR) spectroscopy by examining the changes in the frequency values of major absorptions arising from lipids and proteins. Cluster analysis was used to discriminate the selenium treated group from the control by utilizing two distinct spectral regions, belonging to absorptions arising from lipids and proteins, respectively. In addition, protein secondary structures were predicted using neural network analysis. The results suggest that selenium treatment at a non-toxic dose causes some significant structural alterations in lipids and proteins of rat heart apex and right ventricle myocardia, which might be revealing a slight deleterious effect of selenium supplementation.


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Stan, Cristina; Cristescu, C. P.; Severcan, Feride; Dorohoi, Dana (Informa UK Limited, 2006-01-01)
We present a mathematical approach to the experimental data recorded via Fourier transform-infrared spectroscopy regarding the influence of the concentration of the antimicrobial peptide gramicidin S (GS) on the thermotropic phase transition of the dipalmitoylphosphatidyl-glycerol (DPPG) lipid bilayer membrane in DPPG/GS systems. The model is based on the influence of the GS concentration on the parameters of a nonlinear damped oscillator, which models the CH2 symmetric stretching band.
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Dogan, Ayca; Siyakus, Galip; Severcan, Feride (Elsevier BV, 2007-01-01)
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Şensoy, İlkay; Ho, Chi-Tang; Karwe, Mukund V. (Elsevier BV, 2006-01-01)
The effect of processing on functional compounds in buckwheat was investigated. Extractions of buckwheat flour were carried out before and after roasting or extrusion. Folin-Ciocalteu assays indicated that processing did not cause any change in total phenolic content in buckwheat flour. Roasted (200 degrees C, 10 min) dark buckwheat flour exhibited an increase in non-polar compounds as well as polar compounds whereas extrusion exhibited increase only in polar compounds. Antioxidant activity test (DPPH) show...
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Interactions of a non-steroidal antiestrogen drug, tamoxifen (TAM), with distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) multilamellar liposomes (MLVs) were investigated as a function of drug concentration (1-15 mol%) by using two noninvasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR spectroscopy results show that increasing TAM concentrations (except 1 mol%) increased the wavenumbers of the CH2 stretching modes, implying an disord...
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In the current work, our target was to screen inhibitory potentials of 55 Turkish Salvia taxa, 28 of which are endemic, against acetylcholinesterase (AChE), which is a chief enzyme in pathogenesis of Alzheimer's disease (AD). The dichloromethane, ethyl acetate, and methanol extracts prepared from 55 Salvia taxa were tested for their AChE inhibitory activity at 25, 50, and 100 mu g/ml using an ELISA microplate reader. The extracts were also screened for their scavenging effect against DPPH radical and iron-c...
Citation Formats
N. TOYRAN AL OTAİBİ, F. Severcan, M. Severcan, and B. TURAN, “Effects of selenium supplementation on rat heart apex and right ventricle myocardia by using FTIR spectroscopy: A cluster analysis and neural network approach,” FOOD CHEMISTRY, pp. 590–597, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/56702.