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QSAR study on antibacterial and antifungal activities of some 3,4-disubstituted-1,2,4-oxa(thia)-diazole-5(4 H)-ones(thiones) using physicochemical, quantumchemical and structural parameters
Date
1999-09-01
Author
Geban, Ömer
Yurtsever, M
Ozden, S
Gumus, F
Metadata
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This work demonstrated the quantitative structure-activity relationships of 3,4-disubstituted-1,2,4-oxa(thia)-diazole-5(4 H)-ones (thiones) using quantum chemical parameter R(I), hydrophobicity descriptor and structural parameters. Semiempirical molecular orbital calculations were used to determine the quantum chemical parameter R(I), which is the electron density of HOMO at the sulfur and oxygen in position 1 of the compounds investigated, divided by the orbital energy of HOMO. It was shown that the electron density of HOMO at the sulfur and oxygen of the molecules was strongly related to the biological activities of these molecules. The results obtained from the QSAR application indicated that there was a parabolic dependence between the biological activities and the R(I) index. The structural factor I-Y which shows the presence of a sulfur atom in position 1 was the dominant predictor for the antibacterial and antifungal activities. On the other hand, the other structural variable I-X which shows the presence of a sulfur atom double bonded to the C atom in position 5 caused a decrease, but the hydrophobicity of the whole molecule (Sigma) caused an increase in activity. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
Subject Keywords
3,4-disubstituted-1,2,4-oxa(thia)-diazole-5(4 H)-ones(thiones)
,
QSAR
,
Antibacterial activity
,
Antifungal activity
,
Quantum chemical calculations
URI
https://hdl.handle.net/11511/36296
Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI
https://doi.org/10.1016/s0223-5234(99)00218-4
Collections
Department of Mathematics and Science Education, Article
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Ö. Geban, M. Yurtsever, S. Ozden, and F. Gumus, “QSAR study on antibacterial and antifungal activities of some 3,4-disubstituted-1,2,4-oxa(thia)-diazole-5(4 H)-ones(thiones) using physicochemical, quantumchemical and structural parameters,”
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
, pp. 753–758, 1999, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36296.