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Quantitative structure-activity relationship study of some 7-substituted theophyllines

1998-01-01
Türker, Burhan Lemi
Akgun, H
Balkan, A
Some novel 7-substituted theophylline derivatives have been investigated for quantitative structure-activity relationship (QSAR). For this purpose, their bronchodilatory activities (in vitro), which were examined by the inhibition of acetylcholine induced contraction in tracheae isolated from guinea pigs, have been correlated with various quantum chemical and physicochemical parameters.