Evaluation of [In-111]-Labeled Zinc-Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection

Rice, Douglas R.
Plaunt, Adam J.
Türkyılmaz, Serhan
Smith, Miles
Wang, Yuzhen
Rusckowski, Mary
Smith, Bradley D.
This study prepared three structurally related zinc-dipicolylamine (ZnDPA) tracers with [In-111] labels and conducted biodistribution and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging studies of a mouse leg infection model.


Assessment of effects of multi drug resistance on dielectric properties of K562 leukemic cells using electrorotation
Bahrieh, Garsha; Erdem, Murat; Ozgur, Ebru; Gündüz, Ufuk; Külah, Haluk (2014-01-01)
In this study, dielectric characterization of multidrug resistant (MDR) K562 human leukemia cells was carried out using a MEMS based electrorotation (ER) device with 3D electrodes. P-glycoprotein (P-gp) dependent MDR causes variation in cell dielectric properties (cell interior conductivity (sigma(i)), membrane capacitance (C-m) and total effective membrane conductance (G(m)*)) due to overexpression of P-gp, which modulates the activity of membrane-bound Cl- channels. Different cell populations resistant to...
Eyüboğlu, Behçet Murat; WOLF, PD (IOP Publishing, 1994-01-01)
In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in this study. A statistically constrained minimum-mean-square error estimator (MIMSEE) that minimizes the effects of linearization errors and instrumentation noise is developed and compared to the c...
Design of a Novel THz Sensor for Structural Health Monitoring Applications
Pavia, J. P.; Ribeiro, M. A.; Sarikaya, C. K.; Akbar, D.; Altan, Hakan; Souto, N. (2019-01-01)
In this paper, we propose a study on the characterization, design and simulation of a THz sensor for applications in Structural Health Monitoring (SHM). The proposed sensor is assembled using two frequency selective surfaces (FSSs) based on metamaterial wire resonators. We present a theoretical model to describe its electromagnetics which is used not only to understand the physical principles underlying the functioning of the sensor but also to determine a set of optimized parameters for its operation in th...
Improving the sub-cortical gm segmentation using evolutionary hierarchical region merging
Çiftçioğlu, Mustafa Ulaş; Gökçay, Didem; Department of Medical Informatics (2011)
Segmentation of sub-cortical Gray Matter (GM) structures in magnetic resonance brain images is crucial in clinic and research for many purposes such as early diagnosis of neurological diseases, guidance of surgical operations and longitudinal volumetric studies. Unfortunately, the algorithms that segment the brain into 3 tissues usually suffer from poor performance in the sub-cortical region. In order to increase the detection of sub-cortical GM structures, an evolutionary hierarchical region merging approa...
Mercadier, Deniz Sayin; Beşbınar, Beril; Frossard, Pascal (2019-01-01)
Accurate and fast segmentation of nuclei in histopathological images plays a crucial role in cancer research for detection and grading, as well as personal treatment. Despite the important efforts, current algorithms are still suboptimal in terms of speed, adaptivity and generalizability. Popular Deep Convolutional Neural Networks (DCNNs) have recently been utilized for nuclei segmentation, outperforming traditional approaches that exploit color and texture features in combination with shallow classifiers o...
Citation Formats
D. R. Rice et al., “Evaluation of [In-111]-Labeled Zinc-Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection,” MOLECULAR IMAGING AND BIOLOGY, pp. 204–213, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36681.