Effect of FMD vaccination schedule of dams on the level and duration of maternally derived antibodies

Date

2019-11-01

Author

Sareyyupoglu, B.
Gulyaz, V.
Cokcaliskan, C.
Unal, Y.
Cokulgen, T.
Uzunlu, E.
Gurcan, S.
İlk Dağ, Özlem

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

188
views

0
downloads

Vaccination against Foot and Mouth Disease (FMD) in pregnant cows is crucial to produce greater immunity in new born calves, especially in late gestation, as this directly affects neonatal immunity. Therefore, we aimed to investigate how late gestation FMD vaccination of pregnant cows affects the maternally derived antibodies in their offspring. Pregnant cows were vaccinated with and without booster vaccination during the 3rd months (early gestation vaccination, EGV) or the 6.5th months (late gestation vaccination, LGV). Their offspring were investigated for passive immunity transfer, maternal antibody duration, and the first vaccination age of calves (when the maternal antibody has waned sufficiently to allow the first vaccination). Antibody titers were analyzed by a virus neutralization test (VNT). A digital Brix refractometer (% Brix) was used to estimate passive antibody transfer efficiency measuring total protein (TP) content of calf blood sera and also colostrum IgG content. Two linear mixed effects models were fitted: one for the antibody titer values of the dams, and the other for the antibody titer values of calves before the vaccination. A marginal fixed effects model was also fitted to explore the effects of the dam titers on the antibody titers of the calves after their vaccinations. As a result, the average neutralizing antibody titers did not differ between the EGV and LGV groups nor were any differences detected between dams that received a booster and those that were not boosted. However, the LGV calves' mean maternally derived antibody titers were significantly higher (p-values = 0.0001 for both groups) and the duration was longer than that of the EGV calves (120 days in LGV, 60 days in EGV, p < 0.05). Since no statistical difference was found between the titers of either group of dams at the beginning of the experiment and parturition, it does not appear that the higher VN titers in LGV calves compared to titers in EGV are directly related to the circulating antibody levels in the dams. Furthermore, the TP value (% Brix) of calf blood sera was higher than > 8.4% in both calf groups (9.3 +/- 0.33 in LGV and 8.6 +/- 0.40 in EGV, p > 0.05) indicating that passive immunity transfer had occurred for both groups. In addition, we found that the % Brix mean colostrum IgG content of the LGV (25.8 +/- 1.30) was higher than the EGV (21.8 +/- 0.58) dams (p < 0.01) and a significant positive correlation found between the colostrum density of LGV dams and TP (% Brix) value of their offspring (r = 0.73, p < 0.01). Our results show that vaccination during the late gestation period increased the colostrum IgG content of dams of LGV in addition to the maternally derived antibody duration and potentially provided greater protection of the offspring.

Subject Keywords

Immunology, General Veterinary

URI

https://hdl.handle.net/11511/37436

Journal

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

DOI

https://doi.org/10.1016/j.vetimm.2019.109881

Collections

Department of Statistics, Article

Suggestions

OpenMETU
Core

Fecal shedding of, antimicrobial resistance in, and serologic response to SalmonellaTyphimurium in dairy calves Alexander, Kimberly A.; Warnick, Lorin D.; Cripps, Chris J.; McDonough, Patrick L.; Grohn, Yrjo T.; Wiedmann, Martin; Reed, Kelly E.; James, Karen L.; Soyer, Yeşim; Ivanek, Renata (American Veterinary Medical Association (AVMA), 2009-09-15) Objective-To determine the duration of fecal shedding of and serologic response to Salmonella spp after natural infection in dairy calves and characterize Salmonella organisms recovered from these herds.
Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors. Coban, C; Ishii, KJ; Gürsel, Mayda; Klinman, DM; Kumar, N (Wiley, 2005-09-01) DNA vaccines, in general, have been found to be poorly immunogenic in nonhuman primates and humans as compared with mice. As the immunogenicity of DNA plasmids relies, to a large extent, on the presence of CpG motifs as built in adjuvants, we addressed the issue of poor immunogenicity by inserting recently identified CpG oligonucleotides (ODN) optimal for human (K-type or D-type CpG ODN) into the backbone of plasmid VR1020. We found that plasmid DNA containing K-type CpG motifs or D-type CpG motifs signific...
Effect of suppressive DNA on CpG-induced immune activation. Yamada, H; Gursel, I; Takeshita, F; Conover, J; Ishii, KJ; Gürsel, Mayda; Takeshita, S; Klinman, DM (The American Association of Immunologists, 2002-11-15) Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate a strong innate immune response. This stimulation can be abrogated by either removing the CpG DNA or adding inhibitory/suppressive motifs. Suppression is dominant over stimulation and is specific for CpG-induced immune responses (having no effect on LPS- or Con A-induced activation). Individual cells noncompetitively internalize both stimulatory and suppressive ODN. Studies using ODN composed of both stimula...
Why were Turks unwilling to accept the A/H1N1 influenza-pandemic vaccination? People's beliefs and perceptions about the swine flu outbreak and vaccine in the later stage of the epidemic Gaygisiz, Ummugulsum; Gaygısız Lajunen, Esma; Özkan, Türker; Lajunen, Timo (Elsevier BV, 2010-12-16) This study investigated the acceptability of the A/H1N1 influenza vaccination and related factors among 1137 adults in the later stage of the A/H1N1 outbreak in Turkey. Having already been vaccinated or intending to get vaccinated were related to trust in the vaccine effectiveness, perceived risk of the side effects, and benefits of getting vaccinated. Perceived long term consequences of the A/H1N1 infection, perceptions of the A/H1N1 information in media, and barriers for getting vaccinated were related to...
Effects of purified and non-purified paper plant effluents on fertilization and development of sea urchin Paracentrotus lividus Lam, eggs Uysal, Zahit (1996-01-01) The gametes and embryos of Paracentrotus lividus were exposed to purified and nonpurified effluents of a paper plant together with tap water. The toxicity of purified and non-purified effluents were resembled. Most severe pathologic cases were evident with the tap water. In general, developmental defects were increased with decreasing salinity at all test solutions.

Citation Formats

B. Sareyyupoglu et al., “Effect of FMD vaccination schedule of dams on the level and duration of maternally derived antibodies,” VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, pp. 0–0, 2019, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37436.