Altitudinal Effects on Innate Immune Response of a Subterranean Rodent

Download

index.pdf

Date

2020-02-01

Author

Solak, Halil Mert
Yanchukov, Alexey
Colak, Faruk
MATUR, FERHAT
Sozen, Mustafa
Ayanoğlu, İhsan Cihan
Winternitz, Jamie C.

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

116
views

57
downloads

Immune defense is costly to maintain and deploy, and the optimal investment into immune defense depends on risk of infection. Altitude is a natural environmental factor that is predicted to affect parasite abundance, with lower parasite abundance predicted at higher altitudes due to stronger environmental stressors, which reduce parasite transmission. Using high and low altitude populations of the Turkish blind mole-rat (TBMR) Nannospalax xanthodon, we tested for effects of altitude on constitutive innate immune defense. Field studies were performed with 32 wild animals in 2017 and 2018 from two low- and one high-altitude localities in the Central Taurus Mountains, at respective altitudes of 1010 m, 1115 m, and 2900 m above sea level. We first compared innate standing immune defense as measured by the bacteria-killing ability of blood serum. We then measured corticosterone stress hormone levels, as stressful conditions may affect immune response. Finally, we compared prevalence and intensity of gastrointestinal parasites of field-captured TBMR. We found that the bacteria-killing ability of serum is greater in the mole-rat samples from high altitude. There was no significant difference in stress (corticosterone) levels between altitude categories. Coccidian prevalence and abundance were significantly higher in 2017 than 2018 samples, but there was no significant difference in prevalence, abundance, or intensity between altitudes, or between sexes. Small sample sizes may have reduced power to detect true differences; nevertheless, this study provides support that greater standing innate immunity in high altitude animals may reflect greater investment into constitutive defense.

Subject Keywords

Animal Science and Zoology

URI

https://hdl.handle.net/11511/37453

Journal

ZOOLOGICAL SCIENCE

DOI

https://doi.org/10.2108/zs190067

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Applicability of optimised in-vessel food waste composting for windrow systems Çekmecelioğlu, Deniz; Graves, RE; Davitt, NH (Elsevier BV, 2005-08-01) The presence of pathogens in various organic wastes requires careful attention to the composting process to minimise the chance of their survival. An optimised composting mixture from previous in-vessel composting studies (50% food waste, 40% manure, and 10% bulking agent) was evaluated using windrow composting. Conventional layering and mixing methods were used for constructing the windrows. Temperature was monitored as the indication of the efficiency of composting. Initial and final physico-chemical char...
Cytotoxic T Lymphocyte Activation Signals Modulate Cytoskeletal Dynamics and Mechanical Force Generation Pathni, Aashli; Özçelikkale, Altuğ; Rey-Suarez, Ivan; Li, Lei; Davis, Scott; Rogers, Nate; Xiao, Zhengguo; Upadhyaya, Arpita (2022-03-01) Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co-stimulatory signals required for complete activation. Activated CTLs secrete lytic granules containing enzymes that trigger target cell death at the CTL-target contact, also known as the immune synapse (IS). The actin and microtubule cytoskeletons are instrumental ...
Variation in cold tolerance in F6 durum wheat [ Triticum turgidum (L.) Tell. convar. durum (Desf.) Mackey] RILs and the relationships of cold tolerance with some quality parameters and genetic markers Göçmen Taşkln, Belgin; Özbek, Özlem; Keskin San, Sibel; Eser, Vehbi; Nachit, Miloudi Mikael; Kaya, Zeki (Cambridge University Press (CUP), 2020-03-01) Low temperature is one of the critical factors for determining agricultural production. Therefore, the main objective was to develop the durum wheat lines, which are tolerant to cold particularly in Central Anatolia. The recombinant inbred lines (RILs) (141) derived from F-6 progeny of durum wheat, developed from Kunduru-1149 (female parent) and Cham-1 (male parent) cross, were characterized in terms of their cold tolerance both in the field and under controlled (in growth chamber) conditions. A 0-9 scale w...
Functional characterization of 15-lipoxygenase-1 expression in human colorectal carcinoma cell line ht-29 Tunçay, Seda; Banerjee, Sreeparna; Department of Biology (2009) Colorectal carcinoma (CRC) is often lethal when invasion and/or metastasis occur. 15-lipoxygenase-1 (15-LO-1), an enzyme of the inflammatory eicosanoid pathway, oxidatively metabolizes linoleic acid and its expression is repressed in CRC. In the present study, the hypothesis that the lack of 15-LO-1 expression in CRC cells may contribute to the tumorigenesis was investigated. Therefore 15-LO-1 was introduced to colon cancer cell line HT-29 that does not have detectable levels of the 15-LO-1. The HT-29 cells...
An in vitro mechanical comparison of tibial plateau levelling osteotomy plates Bordelon, J.; Çöker, Demirkan; Payton, M.; Rochat, M. (Georg Thieme Verlag KG, 2009-01-01) An in vitro mechanical study was performed to compare the fatigue properties and the loads to failure of four plate designs that are used to stabilise the tibial plateau levelling osteotomy (TPLO). Seventy-two gapped osteotomy models were created using 3.5 mm versions of the following plates: a standard TPLO plate, a low profile TPLO plate, a locking TPLO plate (LocP), and a broad locking TPLO plate (bLocP). The 18 constructs for each plate design were sub-divided into three identical groups of six. Six con...

Citation Formats

H. M. Solak et al., “Altitudinal Effects on Innate Immune Response of a Subterranean Rodent,” ZOOLOGICAL SCIENCE, pp. 31–41, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37453.