Computational Modeling of Myocardial Infarction

Berberoglu, Ezgi
Göktepe, Serdar
Recent developments in computer technology and mathematical modeling have lead to a remarkable improvement in the computational modeling of the cardiovascular system. The virtual heart models have huge potential to understand the electrophysiological and mechanical response of the heart in the healthy and pathological cases. The simulation of physidogical behavior of the heart depends on the usage of physiologically sound constitutive models besides the incorporation of the efficient, robust, and stable numerical algorithms. In this contribution, the conservation of linear momentum and excitation equation in the Eulerian setting arc solved monolithically through an entirely finite-element based implicit algorithm. The incorporation of the novel generalized Hill model enables us to combine the advantageous features of the active stress and active-strain models. The evolution of the left ventricular pressure is incorporated by a Windkessel-like model. The proposed model is then used to investigate the effect of the myocardial infarction on the pressure-volume curves. (C) 2014 The Authors. Published by Elsevier B.V.


Computational modeling of cardiac dysfunctions
Berberoğlu Yılmaz, Ezgi; Göktepe, Serdar; Department of Civil Engineering (2014)
Computational modeling of the cardiovascular system has improved remarkably with the advances in the computer technology and mathematical modeling. The cardiac models can play a crucial role in understanding the major electromechanical, biophysical, and biochemical processes for the both healthy and pathological cases. The capability of heart models to capture the real physiological behavior depends on physiologically sound constitutive models accounting for the intrinsically non-linear, electromechanically...
Simulation of dynamical refractive index change in on-chip optical devices
Aslan, Anıl; Kocaman, Serdar; Department of Electrical and Electronics Engineering (2019)
Theoretical modeling and numerical verification are essential in integrated photonics for designing optimized structures as well as interpretation of the experimental results. In this thesis, a dynamically changing refractive index modification for the Finite Difference Time Domain (FDTD) method is proposed, implemented with C++ and results are compared with recent experimental studies. The proposed method is based on the idea of the time-domain simulation of the non-stationary objects while satisfying the ...
Investigation of deformation and shape memory characteristics of thermoplastic polymers
Yiğitbaşı, Cihan; Dal, Hüsnü; Department of Mechanical Engineering (2018)
Algorithmic implementation of constitutive models for shape memory polymers into commercial software packages through user material interfaces is the subject of this thesis. The effect of temperature change on the behaviors of these materials has been examined. The formulation of the generated material model has been constructed in the logarithmic strain space. Material model structure consists of three main steps. (i) In the geometric pre-processing step, using current and plastic metric, total and plastic...
Application of Continuum Damage Mechanics in discontinuous crack formation: Forward extrusion chevron
Soyarslan, Celal; TEKKAYA, AHMET ERMAN; Akyüz, Uğurhan (2008-06-01)
Materializing Continuum Damage Mechanics (CDM), numerical modeling of discrete internal cracks, namely central bursts, in direct forward extrusion process is presented. Accordingly, in a thermodynamically consistent setting, a local Lemaitre variant damage model with quasi-unilateral evolution is coupled with hyperelastic-plasticity. The formulations are constructed in the principal axes where simultaneous local integration schemes are efficiently developed. To this end, the framework is implemented as ABAQ...
Comparison of 3D Versus 4D Path Planning for Unmanned Aerial Vehicles
Cicibas, Halil; Demir, Kadir Alpaslan; ARICA, NAFİZ (2016-11-01)
This research compares 3D versus 4D (three spatial dimensions and the time dimension) multi-objective and multi-criteria path-planning for unmanned aerial vehicles in complex dynamic environments. In this study, we empirically analyse the performances of 3D and 4D path planning approaches. Using the empirical data, we show that the 4D approach is superior over the 3D approach especially in complex dynamic environments. The research model consisting of flight objectives and criteria is developed based on int...
Citation Formats
E. Berberoglu and S. Göktepe, “Computational Modeling of Myocardial Infarction,” 2014, Accessed: 00, 2020. [Online]. Available: