INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION

Date

1994-11-01

Author

ISCAN, M
ROSTAMI, H
ISCAN, M
Güray, Nülüfer Tülün
PELKONEN, O
RAUTIO, A

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

56
views

0
downloads

One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.

Subject Keywords

Coumarin, Coumarin 7-hydroxylation, Interindividual variability, Polymorphism

URI

https://hdl.handle.net/11511/37689

Journal

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

DOI

https://doi.org/10.1007/bf00191161

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Dynamics of elderly-caregiving among different socioeconomic groups in Ankara, Turkey Sel, Gizem Irmak; Beşpınar Akgüner, Fatma Umut; Department of Gender and Women's Studies (2017) In the last 20 years, the number of older adults aged 60 and over has been increasing in Turkey in accordance with the increased life expectancy. Accordingly, the needs of ageing population are also changing. However, ageing studies in Turkey do not focus on how these new dynamics are experienced by families. This thesis focuses on how elderly-caregiving is experienced among different socio-economic groups and the effects of this responsibility on their family relations. The study defines caring labour as c...
Intergenerational transmission of maternal war-related trauma experiences to their offspring’s well-being among Turkish Cypriots : mediator role of parenting styles Özüorçun Küçükertan, Nurten; Karancı, Ayşe Nuray; Department of Psychology (2013) The current thesis aimed to study the possible intergenerational transmission of war-related trauma experiences of mothers on their offspring’s current psychological well-being among Turkish Cypriots. The mediator role of mother’s parenting styles within this possible transmission was investigated. In order to examine this relationship, 168 Turkish Cypriot mothers and their child was given different sets of questionnaires. The mothers reported their war-trauma exposure on “War-Trauma Exposure Scale” regardi...
Detection of BCR/ABL gene rearrangement and the elimination of rearranged clone in chronic myelocytic leukemia patients Eren, E; Aytac, U; Tetik, E; Akman, O; Kansu, E; Gündüz, Ufuk (2000-02-01) Cytogenetic and molecular studies were performed on 20 interferon-alpha receiving Turkish chronic myelocytic leukemia patients. Four different restriction endonucleases and bcr-G probe were used for southern blot analysis to detect rearrangements of the bcr gene. The RT-PCR method was also applied to detect chimeric bcr/abl mRNA. Seventeen patients showed a chromosomal break within the 5.8 kb M-bcr region by southern blot analysis while three cases out of 20 have not shown any rearrangement. These three cas...
THE SOCIAL PSYCHOLOGICAL WORLDS OF SWEDES AND TURKS IN AND AROUND RETIREMENT IMAMOGLU, EO; KULLER, R; İmamoğlu, Vacit; KULLER, M (1993-03-01) Five hundred and two Swedish (60 to 71 years of age) and 448 Turkish (55 to 71 years of age) respondents of both genders were interviewed in depth concerning the characteristics of their social networks and evaluations of their current life situations in relation to self-images, life satisfaction, attitudes toward aging, and feelings of loneliness. Results indicated that (a) the Turks, especially men, had both larger social networks and interacted more frequently than the Swedes; (b) compared to Swedes, Tur...
The first year of family- and couple-initiated marriages of a Turkish sample: A longitudinal investigation Hortacsu, N (1999-02-01) One hundred and thirty Turkish couples were interviewed twice during the first year of marriage. One fifth of the couples were involved in traditional family-initiated marriages and the rest were involved in Western-style couple-initiated marriages. The interviews included questions related to demographic measures, marital functioning, and relationships with social network. Analyses revealed earlier parenthood, greater decision power of women for housework-related decisions, and less frequent interaction wi...

Citation Formats

M. ISCAN, H. ROSTAMI, M. ISCAN, N. T. Güray, O. PELKONEN, and A. RAUTIO, “INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION,” EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, pp. 315–318, 1994, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37689.