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INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION
Date
1994-11-01
Author
ISCAN, M
ROSTAMI, H
ISCAN, M
Güray, Nülüfer Tülün
PELKONEN, O
RAUTIO, A
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.
Subject Keywords
Coumarin
,
Coumarin 7-hydroxylation
,
Interindividual variability
,
Polymorphism
URI
https://hdl.handle.net/11511/37689
Journal
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
DOI
https://doi.org/10.1007/bf00191161
Collections
Department of Biology, Article