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INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION

1994-11-01
ISCAN, M
ROSTAMI, H
ISCAN, M
Güray, Nülüfer Tülün
PELKONEN, O
RAUTIO, A
One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.