INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION

Date

1994-11-01

Author

ISCAN, M
ROSTAMI, H
ISCAN, M
Güray, Nülüfer Tülün
PELKONEN, O
RAUTIO, A

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One hundred healthy Turkish Volunteers (70 male, 30 female) aged from 19 to 56 years were given 5 mg coumarin p.o. after an overnight fast. Urine samples were collected before and 2, 4 and 8 h after drug administration. The extent and rate of formation of 7-OH-coumarin (7OHC) was determined by the urinary excretion of the metabolite as measured with the fluorometric method.

Subject Keywords

Coumarin, Coumarin 7-hydroxylation, Interindividual variability, Polymorphism

URI

https://hdl.handle.net/11511/37689

Journal

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

DOI

https://doi.org/10.1007/bf00191161

Collections

Department of Biology, Article

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Citation Formats

M. ISCAN, H. ROSTAMI, M. ISCAN, N. T. Güray, O. PELKONEN, and A. RAUTIO, “INTERINDIVIDUAL VARIABILITY OF COUMARIN 7-HYDROXYLATION IN A TURKISH POPULATION,” EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, pp. 315–318, 1994, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37689.