Nanobiomaterial applications in orthopedics

Christenson, Elizabeth M.
Anseth, Kristi S.
Van Den Beucken, Leroen J. J. P.
Chan, Casey K.
Ercan, Batur
Jansen, John A.
Laurencin, Cato T.
Li, Wan-Ju
Murugan, Ramalingam
Nair, Lakshmi S.
Ramakrishna, Seeram
Tuan, Rocky S.
Webster, Thomas J.
Mikos, Antonios G.
Advancements in nanobiotechnology are revolutionizing our capability to understand biological intricacies and resolve biological and medical problems by developing subtle biomimetic techniques. Nanocomposites and nanostructured materials are believed to play a pivotal role in orthopedic research since bone itself is a typical example of a nanocomposite. This article reviews current strategies using nanobiomaterials to improve current orthopedic materials and examines their applications in bone tissue engineering. Preliminary investigations support the potential of nanobiomaterials in orthopedic applications; however, significant advancements are necessary to achieve clinical use. Overall, current trends in nanobiotechnology foreshadow a bright future through the use of nanobiomaterials in the orthopedic domain. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.


Nanobiomaterials: a review of the existing science and technology, and new approaches
Hasırcı, Vasıf Nejat; Zorlutuna, P.; Ndreu, A.; Yilgor, P.; Basmanav, F. B.; Aydin, E. (2006-01-01)
Nanotechnology has made great strides forward in the creation of new surfaces, new materials and new forms which also find application in the biomedical field. Traditional biomedical applications started benefiting from the use nanotechnology in an array of areas, such as biosensors, tissue engineering, controlled release systems, intelligent systems and nanocomposites used in implant design. In this manuscript a review of developments in these areas will be provided along with some applications from our la...
Yaldız, Burcu; Aydın Son, Yeşim; Department of Medical Informatics (2022-8-31)
Non-linear relationships between genotypes play an essential role in understanding the genetic interactions of complex disease traits. Genome-Wide Association Studies (GWAS) have revealed a statistical association between the SNPs in many complex diseases. As GWAS results could not thoroughly explain the genetic background of these disorders, Genome-Wide Interaction Studies started to gain importance. In recent years, various statistical approaches such as entropy-based methods have been suggested for revea...
Cutting edge: Role of toll-like receptor 9 in CpG DNA-induced activation of human cells
Takeshita, F; Leifer, CA; Gursel, I; Ishii, KJ; Takeshita, S; Gürsel, Mayda; Klinman, DM (The American Association of Immunologists, 2001-10-01)
Unmethylated CpG motifs present in bacterial DNA stimulate a rapid and robust innate immune response. Human cell lines and PBMC that recognize CpG DNA express membrane-bound human Toll-like receptor 9 (hTLR9). Cells that are not responsive to CpG DNA become responsive when transfected with hTLR9. Expression of hTLR9 dramatically increases uptake of CpG (but not control) DNA into endocytic vesicles. Upon cell stimulation, hTLR9 and CpG DNA are found in the same endocytic vesicles. Cells expressing hTLR9 are ...
Development and characterization of silk fibroin and citrus pectin based scaffolds for bone tissue engineering
Ataol, Sibel; Tezcaner, Ayşen; Akdağ, Akın; Department of Biomedical Engineering (2014)
Current strategies of tissue engineering aim to design and develop biologically, physicochemically and mechanically proper scaffolds. Natural polymers are gaining interest in applications since they have already many roles in biochemical pathways and have proper mechanical properties. The objective of this thesis is to develop natural silk fibroin (SF) and citrus pectin (PEC) based three-dimensional porous scaffolds for bone tissue engineering applications. Additionally, we aimed to synthesize nano calcium ...
GeneSelectML: a comprehensive way of gene selection for RNA-Seq data via machine learning algorithms
DAĞ, OSMAN; KAŞIKCI ÇAVDAR, MERVE; İlk Dağ, Özlem; Yesiltepe, Metin (2022-11-01)
Selection of differentially expressed genes (DEGs) is a vital process to discover the causes of diseases. It has been shown that modelling of genomics data by considering relation among genes increases the predictive performance of methods compared to univariate analysis. However, there exist serious differences among most studies analyzing the same dataset for the reasons arising from the methods. Therefore, there is a strong need for easily accessible, user-friendly, and interactive tool to perform gene s...
Citation Formats
E. M. Christenson et al., “Nanobiomaterial applications in orthopedics,” JOURNAL OF ORTHOPAEDIC RESEARCH, pp. 11–22, 2007, Accessed: 00, 2020. [Online]. Available: