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Christenson, Elizabeth M.
Anseth, Kristi S.
Van Den Beucken, Leroen J. J. P.
Chan, Casey K.
Ercan, Batur
Jansen, John A.
Laurencin, Cato T.
Li, Wan-Ju
Murugan, Ramalingam
Nair, Lakshmi S.
Ramakrishna, Seeram
Tuan, Rocky S.
Webster, Thomas J.
Mikos, Antonios G.
Advancements in nanobiotechnology are revolutionizing our capability to understand biological intricacies and resolve biological and medical problems by developing subtle biomimetic techniques. Nanocomposites and nanostructured materials are believed to play a pivotal role in orthopedic research since bone itself is a typical example of a nanocomposite. This article reviews current strategies using nanobiomaterials to improve current orthopedic materials and examines their applications in bone tissue engineering. Preliminary investigations support the potential of nanobiomaterials in orthopedic applications; however, significant advancements are necessary to achieve clinical use. Overall, current trends in nanobiotechnology foreshadow a bright future through the use of nanobiomaterials in the orthopedic domain. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.