Nanobiomaterials: a review of the existing science and technology, and new approaches

Hasırcı, Vasıf Nejat
Zorlutuna, P.
Ndreu, A.
Yilgor, P.
Basmanav, F. B.
Aydin, E.
Nanotechnology has made great strides forward in the creation of new surfaces, new materials and new forms which also find application in the biomedical field. Traditional biomedical applications started benefiting from the use nanotechnology in an array of areas, such as biosensors, tissue engineering, controlled release systems, intelligent systems and nanocomposites used in implant design. In this manuscript a review of developments in these areas will be provided along with some applications from our laboratories.


Polymeric scaffolds for bioactive agent delivery in bone tissue engineering
Uçar, Şeniz; Hasırcı, Nesrin; Yılgör, Pınar; Department of Chemistry (2012)
Tissue engineering is a multidisciplinary field that is rapidly emerging as a promising new approach in the restoration and reconstruction of tissues. In this approach, three dimensional (3D) scaffolds are of great importance. Scaffolds function both as supports for cell growth and depot for sustained release of required active agents (e.g. enzymes, genes, antibiotics, growth factors). Scaffolds should possess certain properties in accordance with usage conditions. Wet-spinning is a simple technique that ha...
Biodegradable nanomats produced by electrospinning: Expanding multifunctionality and potential for tissue engineering
Ashammakhi, N.; Ndreu, A.; Piras, A. M.; Nikkola, L.; Sindelar, T.; Ylikauppila, H.; Harlin, A.; Gomes, M. E.; Neves, N. M.; Chiellini, E.; Chiellini, F.; Hasırcı, Vasıf Nejat; Redl, H.; Reis, R. L. (2007-03-01)
With increasing interest in nanotechnology, development of nanofibers (n-fibers) by using the technique of electrospinning is gaining new momentum. Among important potential applications of n-fiber-based structures, scaffolds for tissue-engineering represent an advancing front. Nanoscaffolds (n-scaffolds) are closer to natural extracellular matrix (ECM) and its nanoscale fibrous structure. Although the technique of electrospinning is relatively old, various improvements have been made in the last decades to...
PCL and PCL-based materials in biomedical applications
Malikmammadov, Elbay; Endoğan Tanır, Tuğba; Kızıltay, Aysel; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2018-01-01)
Biodegradable polymers have met with an increasing demand in medical usage over the last decades. One of such polymers is poly(epsilon-caprolactone) (PCL), which is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strength can be adjusted, and therefore, it can be used under harsh mechanical, physical and chemical co...
Nanobiomaterial applications in orthopedics
Christenson, Elizabeth M.; Anseth, Kristi S.; Van Den Beucken, Leroen J. J. P.; Chan, Casey K.; Ercan, Batur; Jansen, John A.; Laurencin, Cato T.; Li, Wan-Ju; Murugan, Ramalingam; Nair, Lakshmi S.; Ramakrishna, Seeram; Tuan, Rocky S.; Webster, Thomas J.; Mikos, Antonios G. (2007-01-01)
Advancements in nanobiotechnology are revolutionizing our capability to understand biological intricacies and resolve biological and medical problems by developing subtle biomimetic techniques. Nanocomposites and nanostructured materials are believed to play a pivotal role in orthopedic research since bone itself is a typical example of a nanocomposite. This article reviews current strategies using nanobiomaterials to improve current orthopedic materials and examines their applications in bone tissue engine...
Wet spun PCL scaffolds for tissue engineering
Malikmammadov, Elbay; Hasırcı, Nesrin; Endoğan Tanır, Tuğba; Department of Micro and Nanotechnology (2017)
Scaffolds produced for tissue engineering applications are promising alternatives to be used in healing and regeneration of injured tissues and organs. In this study, fibrous poly(ε-caprolactone) (PCL) scaffolds were prepared by wet spinning technique and modified by addition of β-tricalcium phosphate (β-TCP) and by immobilizing gelatin onto fibers. Meanwhile, gelatin microspheres carrying Ceftriaxone sodium (CS), a model antibiotic, were added onto the scaffolds and antimicrobial activity of CS was investi...
Citation Formats
V. N. Hasırcı, P. Zorlutuna, A. Ndreu, P. Yilgor, F. B. Basmanav, and E. Aydin, “Nanobiomaterials: a review of the existing science and technology, and new approaches,” JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, pp. 1241–1268, 2006, Accessed: 00, 2020. [Online]. Available: