Development of pH Sensitive Alginate/Gum Tragacanth Based Hydrogels for Oral Insulin Delivery

Date

2018-11-07

Author

Cikrikci, Sevil
Mert, Behiç
Öztop, Halil Mecit

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

198
views

0
downloads

Insulin entrapped alginate-gum tragacanth (ALG-GT) hydrogels at different ALG replacement ratios (100, 75, 50, 25) were prepared through an ionotropic gelation method, followed by chitosan (CH) polyelectrolyte complexation. A mild gelation process without the use of harsh chemicals was proposed to improve insulin efficiency. Retention of almost the full amount of entrapped insulin in a simulated gastric environment and sustained insulin release in simulated intestinal buffer indicated the pH sensitivity of the gels. Insulin release from hydrogels with different formulations showed significant differences (p < 0.05). Time domain (TD) NMR relaxometry experiments also showed the differences for different formulations, and the presence of CH revealed that ALG-GT gel formulation could be used as an oral insulin carrier at optimum concentrations. The hydrogels formulated from biodegradable, biocompatible, and nontoxic natural polymers were seen as promising devices for potential oral insulin delivery.

URI

https://hdl.handle.net/11511/38211

Journal

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

DOI

https://doi.org/10.1021/acs.jafc.8b02525

Collections

Department of Food Engineering, Article

Suggestions

OpenMETU
Core

Development of amino functionalized POSS based (3-Glycidoxypropyl)trimethoxysilane hybrid sol-gel coatings for aircraft applications Varan, Dilara Çisel; Öztürk, Abdullah; Department of Metallurgical and Materials Engineering (2021-12) An amino functionalized and 50 percent amphiphilic polyhedral oligomeric silsesquioxane (POSS) based (3-Glycidoxypropyl)trimethoxysilane (GPTMS) sol-gel reaction was carried out under extreme basic conditions. Amount of POSS per 1 mol of GPTMS was varied at molar ratios of 0.2, 0.4, and 0.6. The sol-gel product was coated on the aluminium 2024 alloy samples with immersion technique and thermally treated to improve corrosion resistance of the alloy. Influence of aging durations (1, 3, and 6 days) on the sol-...
Synthesis and Characterization of Thiophene and Thieno[3,2-b]thiophene Containing Conjugated Polymers Rustamh, Elvin; Goker, Seza; UDUM, YASEMİN; Udum, Yasemin Arslan; Toppare, Levent Kamil (The Electrochemical Society, 2015-01-01) Herein, we report the synthesis of two donor-acceptor-donor polymers (P1 and P2) based on thiophene (M1) and thieno [3,2-b]thiophene (M2) as the donor and 2,5-bis(dodecyloxy)benzene as the acceptor unit. The effects of different donor units on the polymers' electrochemical and optical properties were examined by cyclic voltammetry and spectroelectrochemical analysis. Introducing thieno[3,2-b]thiophene unit as the donor unit enhances pi-stacking and consequently lowering the bandgap of the resulting polymer....
Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride BAŞAR, Burcin; Tezcaner, Ayşen; Keskin, Dilek; Evis, Zafer (Elsevier BV, 2010-07-01) Hydroxyapatite was doped with Y3+ (2.5, 5 and 7.5 mol%) and F (2.5 mol%) ions (2.5YFHA, 5YFHA, 7.5YFHA, respectively) to compare its structural and mechanical properties and cellular response with pure-hydroxyapatite. No second phases were observed by X-ray diffraction spectra of 2.5YFHA. Doped hydroxyapatites had F- bonds in addition to OH- bonds. Hydroxyapatites sintered at 900 and 1100 degrees C were in nano-size. 7.5YFHA sintered at 1300 degrees C had the highest microhardness value. 2.5YFHA sintered at...
Improving catalytic efficiency in the methanol oxidation reaction by inserting Ru in face-centered cubic Pt nanoparticles prepared by a new surfactant, tert-octanethiol Sen, Fatih; Goekagac, Guelsuen (2008-05-01) PtRu/C catalysts, which have different atomic percent ratios of Pt and Ru (Pt/Ru = 0.8 (catalyst A), 2.1 (catalyst B), and 3.5 (catalyst C)), were prepared using PtCl4 and RuCl3 as starting materials and tert-octanethiol as a surfactant for the first time. Each was characterized by X-ray diffraction, transmission electron microscopy, energy dispersive analysis, X-ray photoelectron spectroscopy, cyclic voltammetry, and elemental analysis, and their activities were determined toward the methanol oxidation rea...
Addition of dibromocarbene to cyclobutene: characterisation and mechanism of formation of the products Algi, Fatih; Hokelek, Tuncer; Balcı, Metin (2004-10-01) Cyclobutene reacted with dibromocarbene in solution to give 1,5-dibromocyclopent-1-ene (9), 1,2,6, 6-tetrabromobicyclo[3.1.0]hexane (10), and 1,2,3,6-tetrabromocyclohex-1-ene (11), in a ratio of 1:4:8, respectively. Compounds 10 and 11 were found to be formed from a second carbene addition and rearrangement under the given reaction conditions.

Citation Formats

S. Cikrikci, B. Mert, and H. M. Öztop, “Development of pH Sensitive Alginate/Gum Tragacanth Based Hydrogels for Oral Insulin Delivery,” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, pp. 11784–11796, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38211.