Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride

Date

2010-07-01

Author

BAŞAR, Burcin
Tezcaner, Ayşen
Keskin, Dilek
Evis, Zafer

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Hydroxyapatite was doped with Y3+ (2.5, 5 and 7.5 mol%) and F (2.5 mol%) ions (2.5YFHA, 5YFHA, 7.5YFHA, respectively) to compare its structural and mechanical properties and cellular response with pure-hydroxyapatite. No second phases were observed by X-ray diffraction spectra of 2.5YFHA. Doped hydroxyapatites had F- bonds in addition to OH- bonds. Hydroxyapatites sintered at 900 and 1100 degrees C were in nano-size. 7.5YFHA sintered at 1300 degrees C had the highest microhardness value. 2.5YFHA sintered at 1100 degrees C had the highest fracture toughness value. MTT viability assays showed high cell attachments on 2.5YFHA. Cell proliferation on 2.5YFHA and 5YFHA sintered at 1100 and 1300 degrees C was comparable with the control after 5-day culture. The highest ALP production and calcium deposition were observed on all hydroxyapatites sintered at 1100 degrees C. 2.5YFHA sintered at 1100 degrees C can be an alternative for hydroxyapatite in orthopedic applications. (C) 2010 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Subject Keywords

Process Chemistry and Technology, Materials Chemistry, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films, Ceramics and Composites

URI

https://hdl.handle.net/11511/48980

Journal

CERAMICS INTERNATIONAL

DOI

https://doi.org/10.1016/j.ceramint.2010.02.033

Collections

Department of Engineering Sciences, Article

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Citation Formats

B. BAŞAR, A. Tezcaner, D. Keskin, and Z. Evis, “Improvements in microstructural, mechanical, and biocompatibility properties of nano-sized hydroxyapatites doped with yttrium and fluoride,” CERAMICS INTERNATIONAL, pp. 1633–1643, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48980.