DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles

Date

2017-02-02

Author

Hoffmann, Thomas
Marıon, Antoıne
Antes, Iris

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Background: T cell receptor (TCR) molecules are involved in the adaptive immune response as they distinguish between self- and foreign-peptides, presented in major histocompatibility complex molecules (pMHC). Former studies showed that the association angles of the TCR variable domains (Va/V beta) can differ significantly and change upon binding to the pMHC complex. These changes can be described as a rotation of the domains around a general Center of Rotation, characterized by the interaction of two highly conserved glutamine residues.

Subject Keywords

Structural Biology

URI

https://hdl.handle.net/11511/38229

Journal

BMC STRUCTURAL BIOLOGY

DOI

https://doi.org/10.1186/s12900-016-0071-7

Collections

Department of Chemistry, Article

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Citation Formats

T. Hoffmann, A. Marıon, and I. Antes, “DynaDom: structure-based prediction of T cell receptor inter-domain and T cell receptor-peptide-MHC (class I) association angles,” BMC STRUCTURAL BIOLOGY, pp. 0–0, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38229.