Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells

Date

2018-08-01

Author

Karaosmanoglu, Oguzhan
Banerjee, Sreeparna
SİVAS, HÜLYA

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Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Complete epithelial to mesenchymal transition (EMT) has long been considered as a crucial step for metastasis initiation. It has, however, become apparent that many carcinoma cells can metastasize without complete loss of epithelial traits or with incomplete gain of mesenchymal traits, i.e., partial EMT. Here, we aimed to determine the similarities and differences between complete and partial EMT through over-expression of the EMT-associated transcription factor Slug in different HCC-derived cell lines.

Subject Keywords

Molecular Medicine, Cancer Research, Oncology, General Medicine

URI

https://hdl.handle.net/11511/38495

Journal

CELLULAR ONCOLOGY

DOI

https://doi.org/10.1007/s13402-018-0384-6

Collections

Department of Biology, Article

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Citation Formats

O. Karaosmanoglu, S. Banerjee, and H. SİVAS, “Identification of biomarkers associated with partial epithelial to mesenchymal transition in the secretome of slug over-expressing hepatocellular carcinoma cells,” CELLULAR ONCOLOGY, pp. 439–453, 2018, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38495.