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Catalytic enantioselective addition of diethylzinc to aldehydes using aziridine based chiral ligands

2007-05-16
BULUT, Adnan
ASLAN, Ayhan
İZGÜ, Enver Cagri
Doğan, Özdemir
The readily available ferrocenyl substituted aziridinylmethanol 1 (FAM-1) was used as a chiral catalyst in the diethylzinc addition reaction to aromatic and aliphatic aldehydes to give secondary alcohols in high yields and up to 99% enantiomeric excess at room temperature. The catalyst can be recovered and used without losing its activity. (c) 2007 Elsevier Ltd. All rights reserved.