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Fast Quantitation of Target Analytes in Small Volumes of Complex Samples by Matrix-Compatible Solid-Phase Microextraction Devices
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Date
2016-06-20
Author
Piri-Moghadam, Hamed
Ahmadi, Fardin
Gomez-Rios, German Augusto
Boyacı, Ezel
Reyes-Garces, Nathaly
Aghakhani, Ali
Bojko, Barbara
Pawliszyn, Janusz
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Herein we report the development of solid-phase microextraction (SPME) devices designed to perform fast extraction/enrichment of target analytes present in small volumes of complex matrices (i.e. V <= 10 mu L). Micro-sampling was performed with the use of etched metal tips coated with a thin layer of biocompatible nano-structured polypyrrole (PPy), or by using coated blade spray (CBS) devices. These devices can be coupled either to liquid chromatography (LC), or directly to mass spectrometry (MS) via dedicated interfaces. The reported results demonstrated that the whole analytical procedure can be carried out within a few minutes with high sensitivity and quantitation precision, and can be used to sample from various biological matrices such as blood, urine, or Allium cepa L single-cells.
Subject Keywords
Coated blade spray
,
Mass spectrometry
,
Small volumes
,
Solid-phase microextraction (SPME)
,
Trace analysis
URI
https://hdl.handle.net/11511/39444
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
DOI
https://doi.org/10.1002/anie.201601476
Collections
Department of Chemistry, Article