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In vivo solid phase microextraction sampling of human saliva for non-invasive and on-site monitoring

Bessonneau, Vincent
Boyacı, Ezel
Maciazek-Jurczyk, Malgorzata
Pawliszyn, Janusz
On-site sample preparation is an analytical approach based on direct sampling from the system under investigation. It has the advantage of combining sampling and sample preparation into a single step, thus generally is fast, minimizes the potential sources of error and eliminates the risks for analytes instability. For such analysis solid phase microextraction in thin film geometry (TF-SPME) can provide robust and convenient in vivo sampling, offering in the same time faster analysis and higher extraction recovery (i.e., better sensitivity) due to large surface to volume ratio.