Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: A longitudinal study in a segmental bone defect model of rabbit

Date

2007-11-01

Author

Balcik, Cenk
Tokdemir, Turgut
Senkoylu, Alpaslan
Koc, Nursen
Timucin, Muharrem
Akın, Serhat
Korkusuz, Petek
Korkusuz, Feza

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Porous interconnected hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) (60/40) ceramics are promising materials for hard tissue repair. However, the mechanical properties of these materials have not been accurately determined under weight-bearing conditions. In this study, newly developed HA and HA/TCP (60/40) ceramics were used with intramedullary fixation in segmental bone defects of rabbits. Early radiological, histological, densitometric and biomechanical changes were evaluated. The mean radiological grade of healing and bonding to bone was higher in HA/TCP (60/40) ceramics than that of pure HA ceramics but the difference was not statistically significant. The densities of both implanted ceramics improved with time, supported by the histological evaluation of bone matrix ingrowth into ceramic pores, whereas the densities at the bone-ceramic interface decreased gradually. Flexural resonant frequencies and three-point bending strength increased, revealing an increase in mechanical stability during this early critical time interval where implant and/or bone-implant interface failures occur frequently. It can be concluded that both HA and HA/TCP (60/40) ceramics have a limited application in the treatment of load-bearing segmental bone defects but did not fail at the early stages of implantation. (C) 2007 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Subject Keywords

Biotechnology, Biochemistry, Molecular Biology, Biomaterials, Biomedical Engineering, General Medicine

URI

https://hdl.handle.net/11511/40473

Collections

Department of Engineering Sciences, Article