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Regulation of Glutathione S-Transferase Mu with type 1 diabetes and its regulation with antioxidants

Kartal, Deniz Irtem
Güray, Nülüfer Tülün
Objective: Increased oxidative stress is now related with the pathogenesis and the chronic complications associated with the disease, diabetes mellitus. While roles of oxidative stress in diabetic complications are widely studied, the molecular mechanisms playing role in the regulations of detoxification enzymes in the presence of antioxidants have not been clearly established because of the complexity of the pathways.