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Human brain evolution: transcripts, metabolites and their regulators
Date
2013-02-01
Author
Somel, Mehmet
Liu, Xiling
Khaitovich, Philipp
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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What evolutionary events led to the emergence of human cognition? Although the genetic differences separating modern humans from both non-human primates (for example, chimpanzees) and archaic hominins (Neanderthals and Denisovans) are known, linking human-specific mutations to the cognitive phenotype remains a challenge. One strategy is to focus on human-specific changes at the level of intermediate phenotypes, such as gene expression and metabolism, in conjunction with evolutionary changes in gene regulation involving transcription factors, microRNA and proximal regulatory elements. In this Review we show how this strategy has yielded some of the first hints about the mechanisms of human cognition.
Subject Keywords
CENTRAL-NERVOUS-SYSTEM
,
HUMAN LIFE-HISTORY
,
GENE-EXPRESSION
,
PREFRONTAL CORTEX
,
POSITIVE SELECTION
,
PRIMATE BRAIN
,
MOLECULAR EVOLUTION
,
GLUCOSE-METABOLISM
,
NATURAL-SELECTION
,
HUMAN UNIQUENESS
URI
https://hdl.handle.net/11511/40619
Journal
NATURE REVIEWS NEUROSCIENCE
DOI
https://doi.org/10.1038/nrn3372
Collections
Department of Biology, Article