Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

Liu, Xiling
Somel, Mehmet
Tang, Lin
Yan, Zheng
Jiang, Xi
Guo, Song
Yuan, Yuan
He, Liu
Oleksiak, Anna
Zhang, Yan
Li, Na
Hu, Yuhui
Chen, Wei
Qiu, Zilong
Paeaebo, Svante
Khaitovich, Philipp
Over the course of ontogenesis, the human brain and human cognitive abilities develop in parallel, resulting in a phenotype strikingly distinct from that of other primates. Here, we used microarrays and RNA-sequencing to examine human-specific gene expression changes taking place during postnatal brain development in the prefrontal cortex and cerebellum of humans, chimpanzees, and rhesus macaques. We show that the most prominent human-specific expression change affects genes associated with synaptic functions and represents an extreme shift in the timing of synaptic development in the prefrontal cortex, but not the cerebellum. Consequently, peak expression of synaptic genes in the prefrontal cortex is shifted from <1 yr in chimpanzees and macaques to 5 yr in humans. This result was supported by protein expression profiles of synaptic density markers and by direct observation of synaptic density by electron microscopy. Mechanistically, the human-specific change in timing of synaptic development involves the MEF2A-mediated activity-dependent regulatory pathway. Evolutionarily, this change may have taken place after the split of the human and the Neanderthal lineages.


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Researchers are still far from thoroughly understanding and building accurate computational models of the mechanisms in human mind that give rise to cognitive processes such as emergence of concepts and language acquisition. As a new attempt to give an insight into this issue, in this thesis, we are concerned about developing a computational model that leads to the emergence of concepts. Speci cally, we investigate how a robot can acquire verb and object concepts through learning affordances, a notion first...
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Brain decoding involves analyzing the cognitive states of human brain by using some statistical techniques in order to understand the relations among the cognitive states, based on neuroimaging data. A very powerful tool to acquire the brain data is functional magnetic resonance images (fMRI), which generates three-dimensional brain volume at each time instant, while a subject performs a cognitive task involving social activities, emotion processing, game playing, memory etc. However, it is very difficult a...
Citation Formats
X. Liu et al., “Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques,” GENOME RESEARCH, pp. 611–622, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/42447.