Metabolic changes in schizophrenia and human brain evolution

Date

2008-01-01

Author

Khaitovich, Philipp
Lockstone, Helen E.
Wayland, Matthew T.
Tsang, Tsz M.
Jayatilaka, Samantha D.
Guo, Arfu J.
Zhou, Jie
Somel, Mehmet
Harris, Laura W.
Holmes, Elaine
Paeaebo, Svante
Bahn, Sabine

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Background: Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA sequence and mRNA expression differences between humans and other primates but, in the absence of other information, it has proved very difficult to identify molecular pathways relevant to human cognition.

Subject Keywords

Magnetic-resonance-spectroscopy, Formal thought-disorder, Gene-expression, Human genome, Positive selection, Nmr-Spectroscopy, Homo-sapiens, Cortex, Proton, Dysfunction

URI

https://hdl.handle.net/11511/38395

Collections

Department of Biology, Article