Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Metabolic changes in schizophrenia and human brain evolution
Download
index.pdf
Date
2008-01-01
Author
Khaitovich, Philipp
Lockstone, Helen E.
Wayland, Matthew T.
Tsang, Tsz M.
Jayatilaka, Samantha D.
Guo, Arfu J.
Zhou, Jie
Somel, Mehmet
Harris, Laura W.
Holmes, Elaine
Paeaebo, Svante
Bahn, Sabine
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
163
views
79
downloads
Cite This
Background: Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA sequence and mRNA expression differences between humans and other primates but, in the absence of other information, it has proved very difficult to identify molecular pathways relevant to human cognition.
Subject Keywords
Magnetic-resonance-spectroscopy
,
Formal thought-disorder
,
Gene-expression
,
Human genome
,
Positive selection
,
Nmr-Spectroscopy
,
Homo-sapiens
,
Cortex
,
Proton
,
Dysfunction
URI
https://hdl.handle.net/11511/38395
Journal
GENOME BIOLOGY
DOI
https://doi.org/10.1186/gb-2008-9-8-r124
Collections
Department of Biology, Article
Suggestions
OpenMETU
Core
Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony
Somel, Mehmet; Liu, Xiling (Elsevier BV, 2014-12-01)
Primate brain transcriptome comparisons within the last 12 years have yielded interesting but contradictory observations on how the transcriptome evolves, and its adaptive role in human cognitive evolution. Since the human-chimpanzee common ancestor, the human prefrontal cortex transcriptome seems to have evolved more than that of the chimpanzee. But at the same time, most expression differences among species, especially those observed in adults, appear as consequences of neutral evolution at cis-regulatory...
Mitochondrial DNA Diversity of Modern, Ancient and Wild Sheep (Ovis gmelinii anatolica) from Turkey: New Insights on the Evolutionary History of Sheep
Demirci, Sevgin; Bastanlar, Evren Koban; Dagtas, Nihan Dilsad; Pişkin, Evangelia; ENGİN, ATİLLA; Ozer, Fusun; Yuncu, Eren; Dogan, Sukru Anil; TOGAN, İNCİ ZEHRA (2013-12-11)
In the present study, to contribute to the understanding of the evolutionary history of sheep, the mitochondrial (mt) DNA polymorphisms occurring in modern Turkish native domestic (n = 628), modern wild (Ovis gmelinii anatolica) (n = 30) and ancient domestic sheep from Oylum Hoyuk in Kilis (n = 33) were examined comparatively with the accumulated data in the literature. The lengths (75 bp/76 bp) of the second and subsequent repeat units of the mtDNA control region (CR) sequences differentiated the five hapl...
Meta analysis of alzheimer’s disease at the gene expression level
İzgi, Hamit; Somel, Mehmet; Department of Biology (2017)
In this study, publicly available microarray gene expression datasets are used to investigate common gene expression changes in different postmortem brain regions in Alzheimer’s Disease (AD) patients compared to control subjects, and to find possible functional associations related to these changes. The hypothesis is that pathogenesis of the disease converges into common patterns of dysregulation/alteration or dysfunction in molecular pathways across different brain regions in AD. In total, I studied 13 dat...
Examining Cognitive Creativity as an Individual Difference in Second Language Acquisition
Pıpes, Ashleıgh Carter(2017-12-31)
This study examines cognitive creativity as an individual difference and its role in processes and outcomes of second language acquisition. The study explores relationships between participants’ creativity, as measured by the Torrance Test of Creative Thinking, and their course grades, narrative structure use, and communication strategy use.
Longitudinal data analysis with statistical and machine learning methods in neuroscience
Çakar, Serenay; Gökalp Yavuz, Fulya; Department of Statistics (2022-8)
Exploration of brain activity under different conditions has been subject to many neuroscience studies. The recent developments in cognitive studies provide the opportunity to work on neural correlates of specific cognitive processes such as working memory, decision making, response inhibition, perception, and sensation. Brain response studies constitute multidimensional, multilevel or nested data sets formed by different parts of the brain of individuals. Hence, it is of significant importance to implement...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
P. Khaitovich et al., “Metabolic changes in schizophrenia and human brain evolution,”
GENOME BIOLOGY
, pp. 0–0, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/38395.