Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer

2016-08-01
Tuncer, S.
ÇAĞATAY, SİBEL
Keskus, A. G.
Colakoglu, M.
KONU KARAKAYALI, ÖZLEN
Banerjee, Sreeparna
ObjectivesMetastasis-associated antigen 1 (MTA1) is implicated in metastasis while 15-lipoxygenase-1 (15-LOX-1) reduces cell motility, when re-expressed in colorectal cancer (CRC). We aimed to understand any potential interplay between MTA1 and 15-LOX-1 in CRC metastasis.
CELL PROLIFERATION

Suggestions

Enrichment of MCF7 breast cancer cells from leukocytes through continuous flow dielectrophoresis
Çağlayan, Zeynep; Külah, Haluk; Department of Electrical and Electronics Engineering (2018)
Circulating tumor cells (CTCs) are cancerous cells detached from a primary tumor site and enter the bloodstream, causing the development of new tumors in a secondary site. Therefore, their detection in blood is critical to assess the metastatic progression and to guide the line of the therapy. However, the rarity of CTCs in the bloodstream and the lack of suitable detection tool hinders their use as a biomarker in malignancies. Recent advances in microfluidic technologies enabled development of point-of-car...
Effect of gemcitabine and retinoic acid loaded PAMAM dendrimer-coated magnetic nanoparticles on pancreatic cancer and stellate cell lines
Yalcin, Serap; Erkan, Mert; Unsoy, Gozde; Parsian, Maryam; Kleeff, Jorg; Gündüz, Ufuk (2014-07-01)
Gemcitabine is an anticancer drug used in the treatment of different cancer types, including pancreatic ductal adenocarcinoma. The maximum tolerated dose in humans is restricted by its side effects on healty cells. Furthermore, the fibrotic stroma produced by the pancreatic stellate cells prevents effective delivery of chemotherapeutic agents providing a safe-haven for the cancer cells. This becomes more of a problem considering the short half-life of this drug. Magnetic nanoparticle-based targeted drug del...
Effect of cisplatin-metformin drug combination on GSTP1 mediated apoptosis
Durukan, Özlem; Arslan, Şevki; Adalı, Orhan (null; 2017-09-08)
Kllng cancer cells by trggerng cellular apoptoss seems to be the prevalent acton mechansm for cancer drugs. Usng substances that targetng the enzymes partcpatng n the apoptotc pathways that trggers the cellular apoptoss can be a useful treatment opton for cancer. GSTP enzyme, ts newly known role as a modulator of cellular survval and death, can be a good proten molecule for cancer studes. Although, csplatn as one of the most potent alkylatng agent that appled wth success n vast majorty of cancers, ts sde ef...
Interaction of tomato lectin with ABC transporter in cancer cells: Glycosylation confers functional conformation of P-gp
Molnar, Joseph; Kars, Meltem Demirel; Gündüz, Ufuk; Engi, Helga; Schumacher, Udo; Van Damme, Els J.; Peumans, Willy J.; Makovitzky, Josef; Gyemant, Nora; Molnar, Peter (2009-01-01)
Phospho-glycoprotein (P-gP) is a polytopic plasma membrane protein whose overexpression causes multidrug resistance (MDR) responsible for the failure of cancer chemotherapy. P-gp 170 is a member of the ATP-binding cassette (ABC) transporter superfamily and has two potentially interesting regions for drugs interfering with its efflux function, namely the oligosaccharides on the first extracellular loop with unknown function and the two intracellular ATP-binding regions providing the energy for drug efflux fu...
Differential alteration of IL-8 in liver cancer stem cell enrichment in response to PI3K/Akt/mTOR inhibitors and sorafenib
Kahraman, Deniz Cansen; Kahraman, Tamer; Atalay, Rengül (2018-07-01)
Liver cancer stem cells (LCSCs) are derived from damaged and transformed hepatic progenitor cells (HPCs) during precancerous cirrhosis stage. Ras/Raf/MAPK and PI3K/AKT/mTOR signaling pathways are significantly deregulated in liver cancer. The activation of PI3K/AKT/mTOR pathway in LCSC population is one of the reasons for acquired resistance to sorafenib in advanced hepatocellular carcinoma (HCC) patients. Therefore, identifying novel inhibitors targeting this pathway acting on LCSCs is highly essential. We...
Citation Formats
S. Tuncer, S. ÇAĞATAY, A. G. Keskus, M. Colakoglu, Ö. KONU KARAKAYALI, and S. Banerjee, “Interplay between 15-lipoxygenase-1 and metastasis-associated antigen 1 in the metastatic potential of colorectal cancer,” CELL PROLIFERATION, pp. 448–459, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41111.