A bio-sensing platform utilizing a conjugated polymer, carbon nanotubes and PAMAM combination

Buber, Ece
Kesik, Melis
Soylemez, Saniye
Toppare, Levent Kamil
In this study, amperometric biosensing performance of a novel platform utilizing a conducting polymer (CP), multi-walled carbon nanotubes (MWCNTs) and poly(amidoamine) (PAMAM) dendrimer was constructed. In order to fabricate the proposed biosensor, a graphite electrode was modified with poly[9,9-di-(2-ethylhexyl)-fluorenyl-2,7-diyl] end capped with N,N-bis(4-methylphenyl)-4-aniline (PFLA), MWCNTs and PAMAM, respectively. Then, GOx was immobilized onto the modified surface with the help of glutaraldehyde (GA) as the crosslinking reagent. Then, analytical and kinetic parameters of the constructed biosensor were investigated and the biosensor showed a linear response for glucose between 0.05 and 0.75 mM with a detection limit of 0.014 mM. K-M(app) and sensitivity values were calculated as 0.66 mM and 55.41 mu A mM(-1) cm(-2), respectively. To investigate the surface modifications, scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques were used. Finally, fabricated biosensor was tested on beverages for glucose detection successfully.


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Immobilization of whole viable Pseudomonas fluorescens cells was achieved on a graphite electrode modified with a thiophene-based conducting polymer. Microbial electrodes were constructed by the entrapment of bacterial cells on conducting copolymer matrix using a dialysis membrane. The biosensor was characterized using glucose as the substrate. As well as analytical characterization, effects of electropolymerization time, pH and temperature on the sensor response were examined. Finally, operational stabilit...
Citation Formats
E. Buber, M. Kesik, S. Soylemez, and L. K. Toppare, “A bio-sensing platform utilizing a conjugated polymer, carbon nanotubes and PAMAM combination,” JOURNAL OF ELECTROANALYTICAL CHEMISTRY, pp. 370–376, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/43889.