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Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species
Date
2016-01-01
Author
TEMEL, HALİDE EDİP
Demirci, Betul
Demirci, Fatih
CELEP, FERHAT
KAHRAMAN, AHMET
Doğan, Musa
Baser, Kemal Husnu Can
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in patients with Alzheimer's disease. This functional role of Salvia species and their components makes the investigations on Salvia valuable in medicine-related plant research. Within this work it was aimed to investigate the in vitro anti-cholinesterase effect of essential oils derived from ten Salvia species, which grow in Turkey. The chemical composition of essential oils were characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), respectively. Results showed that all of the essential oils exhibited AChE inhibitory activity. S. pseudeuphratica, S. hydrangea and S. divaricata essential oils demonstrated the most potent AChE inhibitory effect [ 50% inhibition concentration (IC50) = 26.00 +/- 2.00 mu g/mL, 40.0 +/- 4.00, 64.68 +/- 4.16, respectively]. The essential oil of S. pseudeuphratica demonstrated the highest inhibitory activity against AChE and BuChE among the tested Salvia essential oils. Evidences from the our study augment the importance of essential oils obtained from Salvia species and may support utilization of Salvia species for symptomatic treatment of Alzheimer disease.
Subject Keywords
General Chemistry
URI
https://hdl.handle.net/11511/44176
Journal
JOURNAL OF ESSENTIAL OIL RESEARCH
DOI
https://doi.org/10.1080/10412905.2016.1159257
Collections
Department of Biology, Article