Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species

Date

2016-01-01

Author

TEMEL, HALİDE EDİP
Demirci, Betul
Demirci, Fatih
CELEP, FERHAT
KAHRAMAN, AHMET
Doğan, Musa
Baser, Kemal Husnu Can

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

148
views

0
downloads

Inhibitory effect of Salvia species herbal preparations on acetylcholinesterase (AChE) and butylcholinesterase (BuChE) activitiy may contribute to regulation of cognitive performance and impaired cholinergic functions in patients with Alzheimer's disease. This functional role of Salvia species and their components makes the investigations on Salvia valuable in medicine-related plant research. Within this work it was aimed to investigate the in vitro anti-cholinesterase effect of essential oils derived from ten Salvia species, which grow in Turkey. The chemical composition of essential oils were characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS), respectively. Results showed that all of the essential oils exhibited AChE inhibitory activity. S. pseudeuphratica, S. hydrangea and S. divaricata essential oils demonstrated the most potent AChE inhibitory effect [ 50% inhibition concentration (IC50) = 26.00 +/- 2.00 mu g/mL, 40.0 +/- 4.00, 64.68 +/- 4.16, respectively]. The essential oil of S. pseudeuphratica demonstrated the highest inhibitory activity against AChE and BuChE among the tested Salvia essential oils. Evidences from the our study augment the importance of essential oils obtained from Salvia species and may support utilization of Salvia species for symptomatic treatment of Alzheimer disease.

Subject Keywords

General Chemistry

URI

https://hdl.handle.net/11511/44176

Journal

JOURNAL OF ESSENTIAL OIL RESEARCH

DOI

https://doi.org/10.1080/10412905.2016.1159257

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Phase transition of chemically synthesized FePt nanoparticles under high pressure ŞİMŞEK, TELEM; Karci, Ozgur; ÖZCAN, ŞADAN (The Scientific and Technological Research Council of Turkey, 2018-01-01) We present the results of a study related to phase transformation of chemically synthesized FePt nanoparticles under high pressure from face-centered cubic into face-centered tetragonal structure. As-synthesized nanoparticles are around 4.5 nm and show superparamagnetic behavior at 300 K. After annealing under 60 bar pressure of hydrogen at 400 degrees C for 2 h, nanoparticles exhibit strong ferromagnetic behavior with 5391 Oe coercivity. Results show that high-pressure annealing lowers the decomposition te...
Characterization of Novel O-Glycans Isolated from Tear and Saliva of Ocular Rosacea Patients Özcan Kabasakal, Süreyya; Vieira, Ana C.; Park, Gun Wook; Kim, Jae Han; Mannis, Mark J.; Lebrilla, Carlito B. (American Chemical Society (ACS), 2013-03-01) O-Glycans in saliva and tear isolated from patients suffering from ocular rosacea, a form of inflammatory ocular surface disease, were profiled, and their structures were elucidated using high resolution mass spectrometry. We have previously shown that certain structures, particularly sulfated oligosaccharides, increased in the tear and saliva of rosacea patients In this study, the structures of these glycans were elucidated using primarily tandem mass spectrometry. There were important similarities in the ...
A conjugated gold nanoparticle-azacyanine off-on-off fluorescence probe for sensitive and selective detection of G-quadruplexes Bilgen, Ecenaz; Forough, Mehrdad; Persil Çetinkol, Özgül (Elsevier BV, 2020-09-01) G-quadruplex secondary structures have gained significant recognition due to the discovery of their involvement in regulation of gene expression and their association with many diseases such as cancer and neurological disorders. Consequently, the need for the recognition and characterization of G-quadruplex structures has increased considerably. Here, we present a rapid, facile and sensitive off-on-off in vitro platform for G-quadruplex detection, based on the gold nanoparticle-azacyanine5 (AuNP-Aza5) conju...
Improvement of a liposomal formulation with a native molecule: calcitriol Dalgıç, Ali Deniz; Tezcaner, Ayşen; ARPACI, Fikret; AVCU, Ferit; Keskin, Dilek (Royal Society of Chemistry (RSC), 2016-01-01) Many studies have been conducted to improve liposome's potency towards cancer treatment. Recently, modifications of liposomal formulations turned towards either dual loading of anticancer agents to minimize the dose of each agent or the use of targeting moieties to target them to or near cancer cells for minimizing side effects with maximum treatment. In this study, a natural molecule, calcitriol, was used to improve the effectiveness of doxorubicin loaded liposomes by co-loading approach. Calcitriol treatm...
The design and synthesis of a photo-controlled, peptide-based potential drug carrier Parlak Khalily, Melek; Özçubukçu, Salih (The Scientific and Technological Research Council of Turkey, 2018-01-01) Our focus in this study is on the design and synthesis of a light-responsive peptide-based nanocarrier in order to develop effective and biocompatible drug delivery systems. The synthesized nanocarrier is basically composed of peptide amphiphiles comprising a micelle forming a Pro-Pro-Pro-Lys-Lys-Lys peptide sequence with an attached anthracene fluorophore Anthracene containing an inner core of the micelle can serve as a storage site for poorly water-soluble drugs. Moreover, anthracenes that come in close p...

Citation Formats

H. E. TEMEL et al., “Chemical characterization and anticholinesterase effects of essential oils derived from Salvia species,” JOURNAL OF ESSENTIAL OIL RESEARCH, pp. 322–331, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/44176.