Antioxidant capacities and bioactive compounds of novel thermo-tolerant green microalgae

Bulut, Onur
Accumulation of reactive oxygen species (ROS) at high levels in cells as a result of normal cellular activities as well as exposure to oxidative stress is attributed to many chronic degenerative diseases and conditions in humans including cardiovascular diseases, cancer and aging-related conditions such as Alzheimer's disease. Although living organisms are equipped with enzymatic and non-enzymatic antioxidant defense systems to counteract the adverse effects of oxidative stress, yet they rely on exogenous sources of antioxidants for additional support. Despite, fruits and vegetables are the predominant sources, alternative sources of antioxidants such as microalgae are also being explored. In present study, novel thermo-tolerant green microalgal strains, Scenedesmus sp. ME02, Hindakia tetrachotoma ME03 and Micractinium sp. ME05, were evaluated for their antioxidant capacities, total phenolic, flavonoid and carotenoid contents in various solvent extracts.


Antioxidant activities of Salvia fructosa and its effects on HT 29 cell line
Altay, Ahmet; İrtem Kartal, Deniz; Sağdıçoğlu Celep, Adviye Gülçin; Güray, Nülüfer Tülün; Bozoğlu, Tahsin Faruk (null; 2015-10-01)
Many epidemiological studies have revealed that there is a strong correlation between consumption of polyphenol-rich foods or beverages and the prevention of certain diseases such as cancers, cardiovascular diseases and aging. Phenolic compounds are abundant in all plants, therefore they form an integral part of the human diet. Salvia species, commonly known as sage, have been used since ancient times for more than 60 different ailments ranging from aches to epilepsy. There are around 900 species of Salvia,...
Cancer modeling via biologically validated genes
Karakelle, Barış Su; Purutçuoğlu Gazi, Vilda; Ürün, Yüksel (2017-05-10)
The cancer disease is the second most common disease type seen after the frequency of the cardiovascular diseases. The frequency of this genetic disease changes with respect to the gender. Accordingly, the gynecological cancer, which covers ovarian, endometrial or cervical cancer, is the second most common cancer type in women after the breast cancer. Similar to other cancer types, the gynecological cancer is the system disease, meaning that the malfunctions and mutations in the gene regulatory ...
KAVAS, MUSA; Akca, Oya Ercan; Akcay, Ufuk Celikkol; Peksel, Begum; Eroğlu, Seçkin; Öktem, Hüseyin Avni; Yucel, Meral (2015-01-01)
In this study, the effects of long-term NaCl treatment were investigated in two cultivars of peanut designated as drought-resistant and drought-sensitive. Growth parameters, changes in the concentrations of MDA, H2O2 and proline, and the activities of antioxidant enzymes were determined under salinity stress. Growth parameters indicated the superiority of cv. Florispan to cv. Gazipasa under milder salinity stress treatment. However, comparative analysis of the two cultivars showed that MDA, H2O2, ion leakag...
Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery
Tansik, Gulistan; YAKAR, ARZU; Gündüz, Ufuk (2013-12-07)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells, which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale-based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an exter...
Functional Application Of İmmununoliposomes Encapsulating Celecoxib On Colon Cancer Cell Lines.
Banerjee, Sreeparna(2010-12-31)
Long term regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been correlated with reduced risk of variety of cancers. Celecoxib is a new generation NSAID that can selectively inhibit activity of cyclooxygenase-2 (COX-2) Celecoxib serves as a chemopreventive agent in colorectal cancer. Therefore there is growing interest in developing drug delivery systems for celecoxib, Targeting will be carried out by conjugation of a chimeric monoclonal antibody (Cetuximab) against the Epidermal Growth Fac...
Citation Formats
O. Bulut, “Antioxidant capacities and bioactive compounds of novel thermo-tolerant green microalgae,” Thesis (Ph.D.) -- Graduate School of Natural and Applied Sciences. Biotechnology., Middle East Technical University, 2018.