Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-Fam catalyst

Bulut, Adnan
Aslan, Ayhan
Doğan, Özdemir
Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, alpha,beta-unsaturated, and heteroaromatic) and alpha-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand call be recovered and recycled Without losing its activity.

Citation Formats
A. Bulut, A. Aslan, and Ö. Doğan, “Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-Fam catalyst,” JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 18, pp. 7373–7375, 2008, Accessed: 00, 2020. [Online]. Available: