Breath sensors for lung cancer diagnosis

Date

2015-03-15

Author

Adiguzel, Yekbun
Külah, Haluk

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

159
views

0
downloads

The scope of the applications of breath sensors is abundant in disease diagnosis. Lung cancer diagnosis is a well-fitting health-related application of this technology, which is of utmost importance in the health sector, because lung cancer has the highest death rate among all cancer types, and it brings a high yearly global burden. The aim of this review is first to provide a rational basis for the development of breath sensors for lung cancer diagnostics from a historical perspective, which will facilitate the transfer of the idea into the rapidly evolving sensors field. Following examples with diagnostic applications include colorimetric, composite, carbon nanotube, gold nanoparticle-based, and surface acoustic wave sensor arrays. These select sensor applications are widened by the state-of-the-art developments in the sensors field. Coping with sampling sourced artifacts and cancer staging are among the debated topics, along with the other concerns like proteomics approaches and biomimetic media utilization, feature selection for data classification, and commercialization.

Subject Keywords

Biotechnology, Biophysics, Electrochemistry, Biomedical Engineering, General Medicine

URI

https://hdl.handle.net/11511/47088

Journal

BIOSENSORS & BIOELECTRONICS

DOI

https://doi.org/10.1016/j.bios.2014.10.023

Collections

Department of Electrical and Electronics Engineering, Article

Suggestions

OpenMETU
Core

Highly-sensitive and fast detection of human telomeric G-Quadruplex DNA based on a hemin-conjugated fluorescent metal-organic framework platform Javan Kouzegaran, Vahid; Farhadi, Khalil; Forough, Mehrdad; Bahram, Morteza; Persil Çetinkol, Özgül (Elsevier BV, 2021-04-15) © 2021 Elsevier B.V.The formation of G-quadruplex (G4) structures in Human telomeric DNA (H-Telo) has been demonstrated to inhibit the activity of telomerase enzyme that is associated with the proliferation of many cancer cells. Accordingly, G-quadruplex structures have become one of the well-established targets in anticancer therapeutic strategies. And, the development of simple and selective detection platforms for G4 structures has become a significant focus of research in recent years. In this study, a ...
Interdependence of pulsed ultrasound and shear stress effects on cell morphology and gene expression Mccormick, Susan M.; Saini, Vikas; Yazıcıoğlu, Yiğit; Demou, Zoe N.; Royston, Thomas J. (Springer Science and Business Media LLC, 2006-03-01) Fluid shear stress is a key biomechanical regulatory factor in a several biological systems including bone tissue. Bone cells are also regulated by exogenous acoustic vibration, which has therapeutic benefits. In this study, we determined the effects of shear stress and pulsed ultrasound (US), alone and in series on osteoblast morphology and gene expression. We observed that shear stress (19 dyne/cm(2)) elongated SaOS-2 cells at 3, 6, 24, and 48 h decreasing their shape index from control values of 0.51 +/-...
Direct Write Protein Patterns for Multiplexed Cytokine Detection from Live Cells Using Electron Beam Lithography Lau, Uland Y.; Saxer, Sina S.; Lee, Juneyoung; Bat, Erhan; Maynard, Heather D. (American Chemical Society (ACS), 2016-01-01) Simultaneous detection of multiple biomarkers, such as extracellular signaling molecules, is a critical aspect in disease profiling and diagnostics. Precise positioning of antibodies on surfaces, especially at the micro- and nanoscale, is important for the improvement of assays, biosensors, and diagnostics on the molecular level, and therefore, the pursuit of device miniaturization for parallel, fast, low-volume assays is a continuing challenge. Here, we describe a multiplexed cytokine immunoassay utilizing...
Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering Fathi-Achachelouei, Milad; Keskin, Dilek; Bat, Erhan; Vrana, Nihal E.; Tezcaner, Ayşen (Wiley, 2020-07-01) Degeneration of articular cartilage due to damages, diseases, or age-related factors can significantly decrease the mobility of the patients. Various tissue engineering approaches which take advantage of stem cells and growth factors in a three-dimensional constructs have been used for reconstructing articular tissue. Proliferative impact of basic fibroblast growth factor (bFGF) and chondrogenic differentiation effect of transforming growth factor-beta 1 (TGF-beta 1) over mesenchymal stem cells have previou...
Personalized Remote Monitoring of the Atrial Fibrillation Patients with Electronic Implant Devices Laleci, Gokce; Dogac, Asuman; Yuksel, Mustafa; Kabak, Yildiray; Arbelo, Elena; Danmayr, Franz; Hinterbuchner, Lynne; Chronaki, Catherine; Eichelberg, Marco; Lüpkes, Christian (Hindawi Limited, 2011-6) Cardiovascular Implantable Electronic Devices (CIED) are gaining popularity in treating patients with heart disease. Remote monitoring through care management systems enables continuous surveillance of such patients by checking device functions and clinical events. These care management systems include decision support capabilities based on clinical guidelines. Data input to such systems are from different information sources including medical devices and Electronic Health Records (EHRs). Although evidence-...

Citation Formats

Y. Adiguzel and H. Külah, “Breath sensors for lung cancer diagnosis,” BIOSENSORS & BIOELECTRONICS, pp. 121–138, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/47088.