Biosensing Devices: Conjugated Polymer Based Scaffolds

Soylemez, Saniye
Kesika, Melis
Toppare, Levent Kamil
Conjugated polymer (CP)-based biosensors are recognized to be a next generation building architecture for highly sensitive and fast biosensing systems. This entry highlights an overview on the recent expansion of research in the field of CP-based biosensors. We start by first introducing some of the important knowledge about the CPs and biosensors. This is followed by emphasizing the importance of CPs in biosensor construction. Lastly, an overall survey of CP-based biosensor studies reported between 2010 and 2015 is discussed. Several reviews in literature mostly either refer to a specific enzyme or focus on the techniques of biosensor construction together with general information on conducting polymers. Hence, we tend to emphasize on a number of enzymes studied for the past 5 years.


Fabrication of a promising immobilization platform based on electrochemical synthesis of a conjugated polymer
Buber, Ece; SÖYLEMEZ, SANİYE; UDUM, YASEMİN; Toppare, Levent Kamil (2018-07-01)
Since conjugated polymers are an important class of materials with remarkable properties in biosensor applications, in this study, a novel glucose biosensor based on a conjugated polymer was fabricated via the electropolymerization of the monomer 10,13-bis(4-hexylthiophen-2-yl)dipyridol[3,2-a:2',3'-c]phenazine onto a graphite electrode surface. Glucose oxidase (GOx) was used as the model biological recognition element. As a result of the enzymatic reaction between GOx and glucose, the glucose amount was det...
Bioactive Surface Design Based on Functional Composite Electrospun Nanofibers for Biomolecule Immobilization and Biosensor Applications
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The combination of nanomaterials and conducting polymers attracted remarkable attention for development of new immobilization matrices for enzymes. Hereby, an efficient surface design was investigated by modifying the graphite rod electrode surfaces with one-step electrospun nylon 6,6 nanofibers or 4% (w/w) multiwalled carbon nanotubes (MWCNTs) incorporating nylon 6,6 nanofibers (nylon 6,6/4MWCNT). High-resolution transmission electron microscopy study confirmed the successful incorporation of the MWCNTs in...
Selenium containing conducting polymer based pyranose oxidase biosensor for glucose detection
Gokoglan, Tugba Ceren; SÖYLEMEZ, SANİYE; Kesik, Melis; Toksabay, Sinem; Toppare, Levent Kamil (2015-04-01)
A novel amperometric pyranose oxidase (PyOx) biosensor based on a selenium containing conducting polymer has been developed for the glucose detection. For this purpose, a conducting polymer; poly(4,7-bis(thieno[3,2-b]thiophen-2-yl)benzo[c][1,2,5] selenadiazole) (poly(BSeTT)) was synthesized via electropolymerisation on gold electrode to examine its matrix property for glucose detection. For this purpose, PyOx was used as the model enzyme and immobilised via physical adsorption technique. Amperometric detect...
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In this paper, we propose CLOUDGEN workflow that produces synthetic workloads for Infrastructure and Platform as a Service for the evaluation of resource management approaches in cloud computing systems. To this end, CLOUDGEN systematically processes and clusters records in a given workload trace and fits distributions for different workload parameters within the clusters. Different than the previous work, clustering is carried out to produce different virtual machine types for achieving models that are sui...
Variable connectors in component oriented development
Çetinkaya, Anıl; Doğru, Ali Hikmet; Department of Computer Engineering (2017)
Variability is incorporated in component oriented software development especially in the connectors besides components, for efficient configuration of software products in this thesis. Components have been regarded as the main building blocks in the development of software, especially in component based approaches. Connectors, however, were also part of the solution but with not much of a responsibility when compared to components. When considered in a holistic approach to yield executable code starting wit...
Citation Formats
S. Soylemez, M. Kesika, and L. K. Toppare, Biosensing Devices: Conjugated Polymer Based Scaffolds. 2019, p. 386.