Physical Properties and Erosion Behavior of Poly(trimethylene carbonate-co-epsilon-caprolactone) Networks

Date

2013-05-01

Author

Bat, Erhan
Harmsen, Martin C.
Plantinga, Josee A.
van Luyn, Marja J. A.
Feijen, Jan
Grijpma, Dirk W.

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

121
views

0
downloads

Form-stable resorbable networks are prepared by gamma irradiating trimethylene carbonate (TMC)- and epsilon-caprolactone (CL)-based (co)polymer films. To evaluate their suitability for biomedical applications, their physical properties and erosion behavior are investigated. Homopolymer and copolymer networks that are amorphous at room temperature are flexible and rubbery with elastic moduli ranging from 1.8 +/- 0.3 to 5.2 +/- 0.4MPa and permanent set values as low as 0.9% strain. The elastic moduli of the semicrystalline networks are higher and range from 61 +/- 3 to 484 +/- 34MPa. The erosion behavior of (co)polymer networks is investigated in vitro using macrophage cultures, and in vivo by subcutaneous implantation in rats. In macrophage cultures, as well as upon implantation, a surface erosion process is observed for the amorphous (co)polymer networks, while an abrupt decrease in the rate and a change in the nature of the erosion process are observed with increasing crystallinity. These resorbable and form-stable networks with tuneable properties may find application in a broad range of biomedical applications.

Subject Keywords

Biotechnology, Materials Chemistry, Bioengineering, Polymers and Plastics, Biomaterials

URI

https://hdl.handle.net/11511/48262

Journal

MACROMOLECULAR BIOSCIENCE

DOI

https://doi.org/10.1002/mabi.201200373

Collections

Department of Chemical Engineering, Article

Suggestions

OpenMETU
Core

Trimethylene Carbonate and epsilon-Caprolactone Based (co)Polymer Networks: Mechanical Properties and Enzymatic Degradation Bat, Erhan; Harmsen, Martin C.; van Luyn, Marja J. A.; Zhang, Zheng; Grijpma, Dirk W.; Feijen, Jan (American Chemical Society (ACS), 2008-11-01) High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytotoxicity, surface properties, degradation behavior, and mechanical and thermal properties of these (co)polymers and networks were investigated. Upon incubation with cell culture medium containin...
Thermal stability and decomposition mechanism of poly(p-acryloyloxybenzoic acid and poly(p-methacryloyloxybenzoic acid) and their graft copolymers with polypropylene, Part II Cetin, S.; Tincer, T. (Wiley, 2008-04-05) Thermal stability and decomposition mechanism of poly(p-acryloyloxybenzoic) acid (PABA), p-methacryloyloxybenzoic acid (PMBA), and their graft coproducts of PP were studied by differential scanning calorimetry, direct pyrolysis mass spectrometry, and TG/IR system, combined thermogravimetric analyzer, and FTIR spectrometer. The homopolymers and corresponding grafts were found to be stable in nitrogen atmosphere but started to decompose under atmospheric conditions when heated above 230 degrees C. PABA and PA...
Conducting copolymers of random and block copolymers of electroactive and liquid crystalline monomers with pyrrole and thiophene Camurlu, Pinar; Toppare, Levent Kamil; Yilmaz, Faruk; Yagci, Yusuf; Galli, Giancarlo (Informa UK Limited, 2007-03-01) Block and random copolymers having 3-methyl thienylmethacrylate and 6-(4-cyanobiphenyl-4'-oxy) hexyl acrylate moieties were utilized as precursor polymers in this study. Electrochemical copolymerizations were performed in the presence of thiophene or pyrrole in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB) at constant potential. The characterizations were performed by cyclic voltammetry (CV), fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermal gravime...
Synthetic Design of Polyester Electrolytes Guided by Hydrophobicity Calculations Yıldırım, Erol; Peretic, Matthew J.; Pasquinelli, Melissa A.; Mathers, Robert T. (American Chemical Society (ACS), 2016-10-25) Partition coefficients (LogP) help to quantify hydrophobicity, which can be used to guide the design of polymer electrolytes with properties. Thus, this study combined synthetic experiments and modeling to produce polyester electrolytes that solubilize lithium salts. These polyester electrolytes were derived from natural sources and polymerized with different ratios of polyols (diglycerol, glycerol, and diethylene glycol) and citric acid in the presence of lithium salts (LiTf and LiTFSI). The Fisher esterif...
RADIATION-INDUCED AND ELECTROINITIATED POLYMERIZATION OF ALLYLBENZENE SOUSY, K; USANMAZ, A; Önal, Ahmet Muhtar (Elsevier BV, 1990-08-01) Radiation-induced and electroinitiated polymerization of allylbenzene has been investigated. Radiation-induced polymerization at room temperature was found to give mainly dimers and trimers with a maximum yield of 5%. Electroinitiated polymerization of the monomer yielded insoluble polymer films on the surface of the anode together with low molecular weight polymers in the bulk solution. The effects of temperature and monomer concentration on the rate of electroinitiated polymerization were also studied. Th...

Citation Formats

E. Bat, M. C. Harmsen, J. A. Plantinga, M. J. A. van Luyn, J. Feijen, and D. W. Grijpma, “Physical Properties and Erosion Behavior of Poly(trimethylene carbonate-co-epsilon-caprolactone) Networks,” MACROMOLECULAR BIOSCIENCE, pp. 573–583, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48262.