Trimethylene Carbonate and epsilon-Caprolactone Based (co)Polymer Networks: Mechanical Properties and Enzymatic Degradation

Bat, Erhan
Harmsen, Martin C.
van Luyn, Marja J. A.
Zhang, Zheng
Grijpma, Dirk W.
Feijen, Jan
High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytotoxicity, surface properties, degradation behavior, and mechanical and thermal properties of these (co)polymers and networks were investigated. Upon incubation with cell culture medium containing extracts of (co)polymers and networks, human foreskin fibroblasts remained viable. For all (co)polymers and networks, cell viabilities were determined to be higher than 94%. The formed networks were flexible, with elastic moduli ranging from 2.7 to 5.8 MPa. Moreover, these form-stable networks were creep resistant under dynamic conditions. The permanent deformation after 2 h relaxation was as low as 1% after elongating to 50% strain for 20 times. The in vitro enzymatic erosion behavior of these hydrophobic (co)polymers and networks was investigated using aqueous lipase solutions. The erosion rates in lipase solution could be tuned linearly from 0.8 to 45 Mg/(cm(2) x day) by varying the TMC to CL ratio and the irradiation dose. The copolymers and networks degraded essentially by a surface erosion mechanism.


Physical Properties and Erosion Behavior of Poly(trimethylene carbonate-co-epsilon-caprolactone) Networks
Bat, Erhan; Harmsen, Martin C.; Plantinga, Josee A.; van Luyn, Marja J. A.; Feijen, Jan; Grijpma, Dirk W. (Wiley, 2013-05-01)
Form-stable resorbable networks are prepared by gamma irradiating trimethylene carbonate (TMC)- and epsilon-caprolactone (CL)-based (co)polymer films. To evaluate their suitability for biomedical applications, their physical properties and erosion behavior are investigated. Homopolymer and copolymer networks that are amorphous at room temperature are flexible and rubbery with elastic moduli ranging from 1.8 +/- 0.3 to 5.2 +/- 0.4MPa and permanent set values as low as 0.9% strain. The elastic moduli of the s...
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We report the surface modification of chitosan/poly(ethylene glycol) (chitosan/PEG) hydrogel materials via layer-by-layer (LbL) technique using stimuli-responsive polymers. Water-soluble complexes of Tannic Acid (TA) and a broad-spectrum antibiotic, Ciprofloxacin (Cipro) were prepared and co-assembled at the surface of Chitosan/PEG hydrogels with poly(N-vinyl caprolactam) (PVCL). Compared to the bare hydrogels, the surface spreading and proliferation of human fibroblasts were significantly enhanced on preca...
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A novel proton conducting polymer blend was prepared by mixing poly(vinylphosphonic acid) (PVPA) with poly(1-vinylimidazole) (PVI) at various stoichiometric ratios via changing molar ratio of monomer repeating unit to achieve the highest protonation. The polymer network having the most suitable stoichiometric ratio for substantial proton conductivity was prepared and characterized by FT-IR spectroscopy and proton conductivity measurements. The network was used for immobilization of invertase and some import...
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Semi-empirical molecular orbital calculations at the level of AM1 type have been performed on Huckel type monosilacyclacenes having arenoid rings (R) of 2-7. Silicon atom at the peri and fusion points of arenoid rings were separately considered for each case of R.
Citation Formats
E. Bat, M. C. Harmsen, M. J. A. van Luyn, Z. Zhang, D. W. Grijpma, and J. Feijen, “Trimethylene Carbonate and epsilon-Caprolactone Based (co)Polymer Networks: Mechanical Properties and Enzymatic Degradation,” BIOMACROMOLECULES, pp. 3208–3215, 2008, Accessed: 00, 2020. [Online]. Available: