Streptomyces clavuligerus'ta ccar regülator geninin sefamisin c biyosentezine olan etkisinin transkripsiyonel ve proteom ölçekli analizi

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TVRJeE5UazU.pdf

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2012

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Apak, Aycan
Özcengiz, Gülay
Kızıldoğan, Kurt Aslıhan
Demir, Mustafa

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https://app.trdizin.gov.tr/publication/project/detail/TVRJeE5UazU
https://hdl.handle.net/11511/49730

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Department of Biology, Project and Design

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Targeted disruption of homoserine dehydrogenase gene in Streptomyces clavuligerus and its effects on cephamycin C production Çaydaşı (Koca), Ayşe; Özcengiz, Gülay; Department of Biology (2006) The members of the genus Streptomyces are well-known for their capacity to synthesize a vast repertoire of secondary metabolites, including many useful antibiotics and proteins. Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics such as cephamycin C and the potent β-lactamase inhibitor clavulanic acid. The aspartate pathway of S. clavuligerus is an important primary metabolic pathway providing substrates for β-lactam synthesis. This pathway uses L-aspartic acid as the ...
Effect of homologous multiple copies of aspartokinase gene on cephamycin c biosynthesis in streptomyces clavuligerus Taşkın, Bilgin; Özcengiz, Gülay; Department of Biotechnology (2005) Streptomyces clavuligerus is a gram-positive filamentous bacterium well known for its ability to produce an array of ?-lactam compounds (secondary metabolites) including cephamycin C, clavulanic acid and other structurally related clavams. Of these, cephamycin C is a second generation cephalosporin antibiotic having great medical significance. Biosynthesis of the β-lactam nucleus begins with the non-ribosomal condensation of L-?-aminoadipic acid (?-AAA), L-cysteine and L-valine to form the tripeptide ?-amin...
Streptomyces clavuligerus NRRL3585 ve S. clavuligerus Antibiyotik Aşırı Üretici Mutantlarında Sekonder Metabolit Üretimini Etkileyen Genlerin RNA Seviyesinde Araştırılması Özcengiz, Gülay(2017-12-31) Streptomyces cinsi klinik alanda kullanılan antibiyotiklerin büyük bir çoğunluğunu üretmesiyle tanınmaktadır. Bu antibiyotikler, organizma tarafından ikincil metabolizma sırasında üretilmekte ve genel ismiyle ikincil metabolitler olarak ifade edilmektedir. İkincil metabolitlerin bir kısmı farmakolojik özelliklere sahip olup, antibiyotik, antitumorigenik, antifungal özellikler gösterebilmektedir. Streptomyces clavuligerus türünün ürettiği çeşitli sekonder metabolitler arasında sefamisin C, klavulanik asit, k...
Quantitative expression analysis of the genes potentially involved in clavulanic acid overproduction in streptomyces clavuligerus Aktaş, Caner; Özcengiz, Gülay; Department of Molecular Biology and Genetics (2018) Streptomyces clavuligerus is the producer of the medically important β-lactam antibiotics, including cephamycin C (CC) and the potent β-lactamase inhibitor clavulanic acid. (CA). We have already undertaken an extensive comparative proteomic analysis by using both 2-DE-MALDI-MS and GeLC-MS approaches between an industrial CA overproducer, namely DEPA and the reference strain NRRL3585. In this context, we documented several differentially expressed (over- and under-represented) proteins accounting for high CA...
Streptomyces clavuligerus’ta lysaA ve ccarR genlerinin sefamisin C biyosentezi üzerindeki etkileri Özcengiz, Gülay (null; 2017-12-01)

Citation Formats

A. Apak, G. Özcengiz, K. A. Kızıldoğan, and M. Demir, “Streptomyces clavuligerus’ta ccar regülator geninin sefamisin c biyosentezine olan etkisinin transkripsiyonel ve proteom ölçekli analizi,” 2012. Accessed: 00, 2020. [Online]. Available: https://app.trdizin.gov.tr/publication/project/detail/TVRJeE5UazU.