TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles

Date

2005-10-9

Author

Demir, Ayhan Sıtkı
Aybey, Asuman
Kayalar, Metin

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

2
views

3
downloads

Highly flexible and efficient syntheses of 1,2,3,5-substituted pyrroles starting from 2-propynyl1,3-dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5-exo-dig cyclization of the enaminone intermediate and aromatization.

Subject Keywords

Amination, Cyclization, TFA, 2-propynyl-1, 3-dicarbonyls, Pyrroles

URI

https://hdl.handle.net/11511/50878

Collections

Department of Chemistry, Article