TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles

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10.3998:ark.5550190.0006.f15.pdf

Date

2005-10-9

Author

Demir, Ayhan Sıtkı
Aybey, Asuman
Kayalar, Metin

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Highly flexible and efficient syntheses of 1,2,3,5-substituted pyrroles starting from 2-propynyl1,3-dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5-exo-dig cyclization of the enaminone intermediate and aromatization.

Subject Keywords

Amination, Cyclization, TFA, 2-propynyl-1, 3-dicarbonyls, Pyrroles

URI

https://hdl.handle.net/11511/50878

Journal

Arkivoc

DOI

https://doi.org/10.3998/ark.5550190.0006.f15

Collections

Department of Chemistry, Article

Citation Formats

A. S. Demir, A. Aybey, and M. Kayalar, “TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles,” Arkivoc, vol. 2005, no. 15, pp. 105–116, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/50878.