TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles

2005-10-9
Demir, Ayhan Sıtkı
Aybey, Asuman
Kayalar, Metin
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Highly flexible and efficient syntheses of 1,2,3,5-substituted pyrroles starting from 2-propynyl1,3-dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5-exo-dig cyclization of the enaminone intermediate and aromatization.
Amination, Cyclization, TFA, 2-propynyl-1, 3-dicarbonyls, Pyrroles
https://hdl.handle.net/11511/50878
Department of Chemistry, Article

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Citation Formats
A. S. Demir, A. Aybey, and M. Kayalar, “TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles,” Arkivoc, pp. 105–116, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/50878.
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