TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles

2005-10-9
Demir, Ayhan Sıtkı
Aybey, Asuman
Kayalar, Metin
Highly flexible and efficient syntheses of 1,2,3,5-substituted pyrroles starting from 2-propynyl1,3-dicarbonyl compounds and amines are presented. TFA catalyzed formation of the pyrroles is suggested to proceed through sequential amination of the carbonyl compounds followed by regioselective 5-exo-dig cyclization of the enaminone intermediate and aromatization.
Citation Formats
A. S. Demir, A. Aybey, and M. Kayalar, “TFA catalyzed sequential amination/annulation/aromatization reaction of 2-propynyl-1.3-dicarbonyl compounds with amines: A new one-pot approach to functionalized pyrroles,” Arkivoc, vol. 2005, no. 15, pp. 105–116, 2005, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/50878.