Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Açık Bilim Politikası
Açık Bilim Politikası
Frequently Asked Questions
Frequently Asked Questions
Browse
Browse
By Issue Date
By Issue Date
Authors
Authors
Titles
Titles
Subjects
Subjects
Communities & Collections
Communities & Collections
The effect of low-molecular-weight heparin on rat tendon healing
Download
430-4578.pdf
Date
2009
Author
Esen, Erdinç
Cıla, Erdal
Özoğul, Candan
Taşçı, Arzu Gül
Sipahioğlu, Serkan
Gemalmaz, Halil Can
Öztürk, Akif Muhtar
Doğramacı , Yunus
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
2
views
2
downloads
Objectives: We investigated the effect of low-molecular-weight heparin (LMWH) on the healing of tendons. Methods: Forty-five adult Wistar rats weighing 300 g were randomized into three groups equal in number. All the rats underwent full-thickness surgical incision of the Achilles tendon followed by primary repair. After the operation, two groups received daily subcutaneous LMWH injections (nadroparin calcium) for four weeks at high or low doses (group 1, 6 mg/kg, 170 IU AXa; group II, 3 mg/kg, 85 IU AXa). Group III remained untreated as the control group. Histologically, the specimens were examined under light and electron microscopy with regard to the amount of fibrillar collagen synthesis, mitochondrial degeneration, and the composition of the extracellular matrix collagen. Biomechanically, maximum load to failure and correspondent elongation of the tendons were measured. Results: Compared to the control group, histologically, both LMWH-treated Groups exhibited increased number of fibroblasts, increased fibrillar collagen formation in the extracellular matrix, and higher counts of granular endoplasmic reticula in cytoplasmic contents of fibroblasts as well as decreased mitochondrial vacuolization and degeneration. Biomechanical assessments showed that tendons in group I had significantly higher maximum load to failure and elongation values than group II and III (31 N vs. 24.6 N and 23.1 N; 25 mm vs. 19.6 mm and 17.3 mm, respectively; p<0.05). Group II and III did not differ significantly in this respect (p>0.05). Conclusion: Daily administration of single dose LMWH improves tendon healing through increasing the number of fibroblasts and fibrillar collagen synthesis and decreasing mitochondrial degeneration.
Subject Keywords
Surgery
,
Orthopedics and Sports Medicine
,
General Medicine
,
Achilles tendon/injuries
,
Heparin
,
Low-molecularweight
,
Rats
,
Wound healing
URI
https://hdl.handle.net/11511/50949
Journal
Acta Orthopaedica et Traumatologica Turcica
DOI
https://doi.org/10.3944/aott.2009.054
Collections
Department of Civil Engineering, Article