An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

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10.1155:2016:6741418.pdf

Date

2016-01-01

Author

Yuksel, Mustafa
Gonul, Suat
Erturkmen, Gokce Banu Laleci
Sınacı, Ali Anıl
Invernizzi, Paolo
Facchinetti, Sara
Migliavacca, Andrea
Bergvall, Tomas
Depraetere, Kristof
De Roo, Jos

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Our objective is to improve postmarket safety studies by enabling safety analysts to seamlessly access a wide range of EHR sources for collecting deidentified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs. We have developed an ontological framework where EHR sources and target clinical research systems can continue using their own local data models, interfaces, and terminology systems, while structural interoperability and Semantic Interoperability are handled through rule-based reasoning on formal representations of different models and terminology systems maintained in the SALUS Semantic Resource Set. SALUS Common Information Model at the core of this set acts as the common mediator. We demonstrate the capabilities of our framework through one of the SALUS safety analysis tools, namely, the Case Series Characterization Tool, which have been deployed on top of regional EHR Data Warehouse of the Lombardy Region containing about 1 billion records from 16 million patients and validated by several pharmacovigilance researchers with real-life cases. The results confirm significant improvements in signal detection and evaluation compared to traditional methods with the missing background information.

Subject Keywords

ADVERSE DRUG-REACTIONS, CLINICAL-RESEARCH, MEDICAL INFORMATICS, QUALITY MANAGEMENT, WEB SERVICES, ONTOLOGIES, SYSTEM, TRIALS, CARE, TECHNOLOGIES

URI

https://hdl.handle.net/11511/51024

Journal

BIOMED RESEARCH INTERNATIONAL

DOI

https://doi.org/10.1155/2016/6741418

Collections

Department of Computer Engineering, Article

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Citation Formats

M. Yuksel et al., “An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies,” BIOMED RESEARCH INTERNATIONAL, pp. 0–0, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51024.