An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies

Download

10.1155:2016:6741418.pdf

Date

2016-01-01

Author

Yuksel, Mustafa
Gonul, Suat
Erturkmen, Gokce Banu Laleci
Sınacı, Ali Anıl
Invernizzi, Paolo
Facchinetti, Sara
Migliavacca, Andrea
Bergvall, Tomas
Depraetere, Kristof
De Roo, Jos

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

206
views

121
downloads

Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Our objective is to improve postmarket safety studies by enabling safety analysts to seamlessly access a wide range of EHR sources for collecting deidentified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs. We have developed an ontological framework where EHR sources and target clinical research systems can continue using their own local data models, interfaces, and terminology systems, while structural interoperability and Semantic Interoperability are handled through rule-based reasoning on formal representations of different models and terminology systems maintained in the SALUS Semantic Resource Set. SALUS Common Information Model at the core of this set acts as the common mediator. We demonstrate the capabilities of our framework through one of the SALUS safety analysis tools, namely, the Case Series Characterization Tool, which have been deployed on top of regional EHR Data Warehouse of the Lombardy Region containing about 1 billion records from 16 million patients and validated by several pharmacovigilance researchers with real-life cases. The results confirm significant improvements in signal detection and evaluation compared to traditional methods with the missing background information.

Subject Keywords

ADVERSE DRUG-REACTIONS, CLINICAL-RESEARCH, MEDICAL INFORMATICS, QUALITY MANAGEMENT, WEB SERVICES, ONTOLOGIES, SYSTEM, TRIALS, CARE, TECHNOLOGIES

URI

https://hdl.handle.net/11511/51024

Journal

BIOMED RESEARCH INTERNATIONAL

DOI

https://doi.org/10.1155/2016/6741418

Collections

Department of Computer Engineering, Article

Suggestions

OpenMETU
Core

A Semantic interoperability framework for reinforcing post market safety studies Yüksel, Mustafa; Coşar, Ahmet; Department of Computer Engineering (2013) Depending mostly on voluntarily sent spontaneous reports, pharmacovigilance studies are hampered by low quantity and quality of patient data. Enabling safety analysts to seamlessly access a wide range of Electronic Health Record (EHR) sources for collecting de-identified medical data sets of selected patient populations and tracing the reported incidents back to original EHRs can provide major improvements for such post market safety studies. The adoption of EHR systems and data exchange among these systems...
An Extensible security infrastructure for the secondary use of electronic health records in clinical research Eryılmaz, Elif; Toroslu, İsmail Hakkı; Doğaç, Asuman; Department of Computer Engineering (2013) In order to facilitate clinical research studies re-using Electronic Health Records (EHR) has a great potential. Besides interoperability, safeguarding the security and privacy of the medical data in the context of secondary use for clinical research is one of the most important challenges in this respect. In order to ensure that the clinical information is shared among EHR systems and clinical research systems in an ethical and safe way, there needs to be standards-based and adaptable security and privacy ...
A novel report generation approach for medical applications : the sisds methodology and its applications Kuru, Kaya; Arda, Kemal; Department of Medical Informatics (2010) In medicine, reliable data are available only in a few areas and necessary information on prognostic implications is generally missing. In spite of the fact that a great amount of money has been invested to ease the process, an effective solution has yet to be found. Unfortunately, existing data collection approaches in medicine seem inadequate to provide accurate and high quality data, which is a prerequisite for building a robust and effective DDSS. In this thesis, many different medical reporting methodo...
A Bayesian modeling and estimation framework for pharmacogenomics driven warfaring dosing Öztaner, Serdar Murat; Taşkaya Temizel, Tuğba; Erdem, Remzi; Department of Medical Informatics (2014) Recent studies have shown that the incorporation of genomics information into the drug dosing prediction formulations increases the accuracy of the drug dosing while decreasing the frequency of adverse drug effects. The current clinical approaches for drug dosing which are supported by the best pharmacogenomics algorithms explain only some percentage of the variance in dosing. The main objective of this study is to enhance the accuracy and efficacy of the warfarin dosing algorithms by using advanced methods...
A model to evaluate inventory costs in a remanufacturing environment Bayındır, Zeynep Pelin; Gullu, R (Elsevier BV, 2003-01-11) In this study we investigate possible benefits of remanufacturing in inventory-related costs. In order to examine the conditions on different system parameters that make the remanufacturing option cost attractive, the return ratio is considered as a decision variable. The production environment, where the manufacturing and remanufacturing require both common and separate operations, together with the supplier's operations for the new parts and useful lifetime of the product is modeled as a queuing network. ...

Citation Formats

M. Yuksel et al., “An Interoperability Platform Enabling Reuse of Electronic Health Records for Signal Verification Studies,” BIOMED RESEARCH INTERNATIONAL, pp. 0–0, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51024.