Statistical Approaches for the Analysis of Dependency Among Neurons Under Noise

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10.3390:e22040387.pdf

Date

2020-3-28

Author

Gençağa, Deniz
Ayan, Sevgi Şengül
Farnoudkia, Hajar
Okuyucu, Serdar

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Neuronal noise is a major factor affecting the communication between coupled neurons. In this work, we propose a statistical toolset to infer the coupling between two neurons under noise. We estimate these statistical dependencies from data which are generated by a coupled Hodgkin–Huxley (HH) model with additive noise. To infer the coupling using observation data, we employ copulas and information-theoretic quantities, such as the mutual information (MI) and the transfer entropy (TE). Copulas and MI between two variables are symmetric quantities, whereas TE is asymmetric. We demonstrate the performances of copulas and MI as functions of different noise levels and show that they are effective in the identification of the interactions due to coupling and noise. Moreover, we analyze the inference of TE values between neurons as a function of noise and conclude that TE is an effective tool for finding out the direction of coupling between neurons under the effects of noise.

Subject Keywords

General Physics and Astronomy, Transfer entropy, Mutual information, Information theory, Copulas, Hodgkin-Huxley model

URI

https://hdl.handle.net/11511/51490

Journal

Entropy

DOI

https://doi.org/10.3390/e22040387

Collections

Department of Statistics, Article

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Citation Formats

D. Gençağa, S. Ş. Ayan, H. Farnoudkia, and S. Okuyucu, “Statistical Approaches for the Analysis of Dependency Among Neurons Under Noise,” Entropy, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/51490.