A novel synthesis of 1,2,4-oxadiazoles and isoxazoles

Date

2014-01-28

Author

KIVRAK, Arif
Zora, Metin

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A novel synthesis of 1,2,4-oxadiazoles and isoxazoles is described by utilizing the reactions between amidoximes and alpha,beta-alkynic aldehydes and/or ketones. Conjugate addition products, obtained from amidoximes and alpha,beta-alkynic aldehydes and/or ketones, afford 1,2,4-oxadiazoles and isoxazoles when treated with bases and acids, respectively. 1,2,4-Oxadiazoles can also be synthesized directly from amidoximes and alpha,beta-alkynic aldehydes in a one-pot manner under basic conditions. The reactions are general for a variety of starting compounds and tolerate the presence of aryl, heteroaryl and alkyl groups.

Subject Keywords

Organic Chemistry, Biochemistry, Drug Discovery

URI

https://hdl.handle.net/11511/42653

Journal

TETRAHEDRON

DOI

https://doi.org/10.1016/j.tet.2013.12.043

Collections

Department of Chemistry, Article

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Citation Formats

A. KIVRAK and M. Zora, “A novel synthesis of 1,2,4-oxadiazoles and isoxazoles,” TETRAHEDRON, pp. 817–831, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/42653.