Interactions of tamoxifen with distearoyl phosphatidylcholine multilamellar vesicles: FTIR and DSC studies

Date

2014-09-15

Author

Bilge, Duygu
ŞAHİN, İPEK
KAZANCI, NADİDE
Severcan, Feride

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Interactions of a non-steroidal antiestrogen drug, tamoxifen (TAM), with distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) multilamellar liposomes (MLVs) were investigated as a function of drug concentration (1-15 mol%) by using two noninvasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR spectroscopy results show that increasing TAM concentrations (except 1 mol%) increased the wavenumbers of the CH2 stretching modes, implying an disordering effect for DSPC MLVs both in the gel and liquid crystalline phases. The bandwidth values of the CH2 stretchings except for I mol% increased when TAM concentrations increased for DSPC liposomes, indicating an increase in the dynamics of liposomes. The C=O stretching and PO2- antisymmetric double bond stretching bands were analyzed to study interactions of TAM with head groups of lipids. As the concentrations of TAM increased, dehydration occurred around these functional groups in the polar part of the lipids. The DSC studies on thermal properties of DSPC lipids indicate that TAM eliminated the pre transition, shifted the main phase transition to lower temperatures and broadened the phase transition curve of the liposomes.

Subject Keywords

Instrumentation, Analytical Chemistry, Spectroscopy, Atomic and Molecular Physics, and Optics

URI

https://hdl.handle.net/11511/52228

Journal

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

DOI

https://doi.org/10.1016/j.saa.2014.04.027

Collections

Department of Biology, Article

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Citation Formats

D. Bilge, İ. ŞAHİN, N. KAZANCI, and F. Severcan, “Interactions of tamoxifen with distearoyl phosphatidylcholine multilamellar vesicles: FTIR and DSC studies,” SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, pp. 250–256, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52228.