Interactions of tamoxifen with distearoyl phosphatidylcholine multilamellar vesicles: FTIR and DSC studies

Bilge, Duygu
Severcan, Feride
Interactions of a non-steroidal antiestrogen drug, tamoxifen (TAM), with distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) multilamellar liposomes (MLVs) were investigated as a function of drug concentration (1-15 mol%) by using two noninvasive techniques, namely Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). FTIR spectroscopy results show that increasing TAM concentrations (except 1 mol%) increased the wavenumbers of the CH2 stretching modes, implying an disordering effect for DSPC MLVs both in the gel and liquid crystalline phases. The bandwidth values of the CH2 stretchings except for I mol% increased when TAM concentrations increased for DSPC liposomes, indicating an increase in the dynamics of liposomes. The C=O stretching and PO2- antisymmetric double bond stretching bands were analyzed to study interactions of TAM with head groups of lipids. As the concentrations of TAM increased, dehydration occurred around these functional groups in the polar part of the lipids. The DSC studies on thermal properties of DSPC lipids indicate that TAM eliminated the pre transition, shifted the main phase transition to lower temperatures and broadened the phase transition curve of the liposomes.


Analysis of the Raman intensities near the phase transitions in ammonium halides
Yurtseven, Hasan Hamit (Elsevier BV, 2008-12-01)
This study concentrates on the temperature dependence of the Raman intensities for the lattice modes in ammonium halides (NH4Cl and NH4Br) close to phase transitions, We predict their intensities using the results of a shell model for the Raman polarizability within the framework of an Ising pseudospin-phonon coupled model.
Temperature dependence of the damping constant and the order parameter close to the lambda phase transitions in ammonium halides
Yurtseven, Hasan Hamit (Elsevier BV, 2006-10-01)
This study gives our calculation for the damping constant, using the expressions derived for an Ising pseudospin-phonon coupled system in the ammonium halides (NH4Cl and NH4Br). For this calculation of the damping constant, we use the temperature dependence of the order parameter calculated from the molecular field theory. We predict here the damping constants for the v(5) (174 cm(-1)) and v(5) (177 cm(-1)) Raman modes of NH4Cl and NH4Br, respectively, below T-lambda and compare them with our observed bandw...
2-D analysis of Ge implanted SiO(2) surfaces by laser-induced breakdown spectroscopy
Yalcin, Serife; Oerer, Sabiha; Turan, Raşit (Elsevier BV, 2008-10-01)
2-D elemental distribution of Ge in silicon oxide substrates with differing implantation doses of between 3x10(16) cm(-2) and 1.5x10(17) cm(-2) has been investigated by Laser-induced Breakdown Spectroscopy (LIBS). Spectral emission intensity has been optimized with respect to time, crater size, ablation depth and laser energy. Atomic Force Microscopy (AFM) and Scanning Electron Microscopy (SEM) coupled with Energy-Dispersive X-Ray Spectroscopy (EDX) have been utilized to obtain crater depth, morphology and ...
Quantum chemical studies on some seleanaphthalene derivatives
Türker, Burhan Lemi (Elsevier BV, 2005-04-01)
Quantum chemical studies on certain selenanaphthalene derivatives (having a keto or enol group and also Se atom in five- or six-membered ring system fused with naphthalene moiety) have been carried out using PM3 method at the level of restricted Hartree-Fock approach. The aquated systems have also been considered.
Monte Carlo simulation of transport from an electrothermal vaporizer
Holcombe, James A.; Ertaş, Gülay (Elsevier BV, 2006-06-01)
Monte Carlo simulations were developed to elucidate the time and spatial distribution of analyte during the transport process from an electrothermal vaporizer to an inductively coupled plasma. A time-of-flight mass spectrometer was employed to collect experimental data that was compared with the simulated transient signals. Consideration was given to analyte transport as gaseous species as well as aerosol particles. In the case of aerosols, the simulation assumed formation of 5 nm particles and used the Ein...
Citation Formats
D. Bilge, İ. ŞAHİN, N. KAZANCI, and F. Severcan, “Interactions of tamoxifen with distearoyl phosphatidylcholine multilamellar vesicles: FTIR and DSC studies,” SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, pp. 250–256, 2014, Accessed: 00, 2020. [Online]. Available: