A federated semantic metadata registry framework for enabling interoperability across clinical research and care domains

2013-10-01
Sınacı, Ali Anıl
Erturkmen, Gokce B. Laleci
In order to enable secondary use of Electronic Health Records (EHRs) by bridging the interoperability gap between clinical care and research domains, in this paper, a unified methodology and the supporting framework is introduced which brings together the power of metadata registries (MDR) and semantic web technologies. We introduce a federated semantic metadata registry framework by extending the ISO/IEC 11179 standard, and enable integration of data element registries through Linked Open Data (LOD) principles where each Common Data Element (CDE) can be uniquely referenced, queried and processed to enable the syntactic and semantic interoperability. Each CDE and their components are maintained as LOD resources enabling semantic links with other CDEs, terminology systems and with implementation dependent content models; hence facilitating semantic search, much effective reuse and semantic interoperability across different application domains. There are several important efforts addressing the semantic interoperability in healthcare domain such as IHE DEX profile proposal, CDISC SHARE and CDISC2RDF. Our architecture complements these by providing a framework to interlink existing data element registries and repositories for multiplying their potential for semantic interoperability to a greater extent. Open source implementation of the federated semantic MDR framework presented in this paper is the core of the semantic interoperability layer of the SALUS project which enables the execution of the post marketing safety analysis studies on top of existing EHR systems.
JOURNAL OF BIOMEDICAL INFORMATICS

Suggestions

A Semantically Enriched Clinical Guideline Model Enabling Deployment in Heterogeneous Healthcare Environments
Laleci, Gokce B.; Doğaç, Asuman (Institute of Electrical and Electronics Engineers (IEEE), 2009-03-01)
Clinical guidelines are developed to assist healthcare practitioners to make decisions on patient's medical problems, and as such they communicate with external applications to retrieve patient data to initiate medical actions through clinical workflows, and transmit information to alert/reminder systems. The interoperability problems in the healthcare information technology domain prevent wider deployment of clinical guidelines because each deployment requires a tedious custom adaptation phase. In this pap...
A temporal neural network model for constructing connectionist expert system knowledge bases
Alpaslan, Ferda Nur (Elsevier BV, 1996-04-01)
This paper introduces a temporal feedforward neural network model that can be applied to a number of neural network application areas, including connectionist expert systems. The neural network model has a multi-layer structure, i.e. the number of layers is not limited. Also, the model has the flexibility of defining output nodes in any layer. This is especially important for connectionist expert system applications.
Development of a computer algorithm for feedback controlled electrical nerve fiber stimulation
Doruk, R. Ozgur (Elsevier BV, 2011-09-01)
The purpose of this research is to develop an algorithm for a feedback controlled local electrical nerve fiber stimulation system which has the purpose to stop the repetitive firing in a particular region of the nervous system. The electrophysiological behavior of the neurons (under electrical currents) is modeled by Hodgkin-Huxley (HH) type nonlinear nerve fiber dynamics. The repetitive firing of in the modeled fiber is due to the deviations in the channel parameters, which is also called as bifurcation in...
A hierarchical representation of form documents for identification and retrieval
Duygulu, Pinar; Atalay, Mehmet Volkan (Springer Science and Business Media LLC, 2003-12-01)
In this paper, we present a logical representation for form documents to be used for identification and retrieval. A hierarchical structure is proposed to represent the structure of a form by using lines and the XY-tree approach. The approach is top-down and no domain knowledge such as the preprinted data or filled-in data is used. Geometrical modifications and slight variations are handled by this representation. Logically identical forms are associated to the same or similar hierarchical structure. Identi...
Collaborative Business Process Support in eHealth: Integrating IHE Profiles Through ebXML Business Process Specification Language
Doğaç, Asuman; Kabak, Yildiray; Namli, Tuncay; Okcan, Alper (Institute of Electrical and Electronics Engineers (IEEE), 2008-11-01)
Integrating healthcare enterprise (IHE) specifies integration profiles describing selected real world use cases to facilitate the interoperability of healthcare information resources. While realizing a complex real-world scenario, IHE profiles are combined by grouping the related IHE actors. Grouping IHE actors implies that the associated business processes (IHE profiles) that the actors are involved must be combined, that is, the choreography of the resulting collaborative business process must be determin...
Citation Formats
A. A. Sınacı and G. B. L. Erturkmen, “A federated semantic metadata registry framework for enabling interoperability across clinical research and care domains,” JOURNAL OF BIOMEDICAL INFORMATICS, pp. 784–794, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/52337.