Development of a computer algorithm for feedback controlled electrical nerve fiber stimulation

Date

2011-09-01

Author

Doruk, R. Ozgur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

176
views

0
downloads

The purpose of this research is to develop an algorithm for a feedback controlled local electrical nerve fiber stimulation system which has the purpose to stop the repetitive firing in a particular region of the nervous system. The electrophysiological behavior of the neurons (under electrical currents) is modeled by Hodgkin-Huxley (HH) type nonlinear nerve fiber dynamics. The repetitive firing of in the modeled fiber is due to the deviations in the channel parameters, which is also called as bifurcation in the nonlinear systems theory. A washout filter is augmented to the HH dynamics and then the output of the filter is fed to the external current generator through a linear gain. This gain is computed by linear projective control theory. That is a linear output feedback control technique where the closed loop spectrum of the full state feedback closed loop is partially maintained. By obtaining a spectrum of eigenvalues with completely negative real parts the nerve fibers can be relaxed to the equilibrium point with or without a damped oscillation. The MATLAB script applying the theory of this work is provided at the end of this paper. A MATLAB-Simulink computer simulation is performed in order to verify the algorithm. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

Subject Keywords

Software, Health Informatics, Computer Science Applications

URI

https://hdl.handle.net/11511/63619

Journal

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

DOI

https://doi.org/10.1016/j.cmpb.2010.06.013

Collections

Graduate School of Marine Sciences, Article

Suggestions

OpenMETU
Core

Preliminary results of a novel enhancement method for high-frequency hearing loss Arioz, Umut; Arda, Kemal; Tuncel, Umit (Elsevier BV, 2011-06-01) In this study, a software program was developed for high-frequency hearing loss subjects that includes a detailed audiogram and novel enhancement methods. The software performs enhancements of the audibility of high-frequency sounds according to the subject's detailed 31-point audiogram. This provides subject-specific gains in the entire frequency spectrum, and especially for high frequencies, of sounds. Amplification, compression, and transposition are the three main processing methods used to obtain the d...
Feedback controlled electrical nerve stimulation: A computer simulation Doruk, R. Ozgur (Elsevier BV, 2010-07-01) The role of repetitive firing in neurophysiologic or neuropsychiatric disorders, such as Parkinson, epilepsy and bipolar type disorders, has always been a topic of medical research as therapies target either the cease of firing or a decrease in its frequency. In electrotherapy, one of the mechanisms to achieve the purpose in point is to apply a low density electric current to the nervous system. In this study, a computer simulation is provided of a treatment in which the stimulation current is computed by n...
Evaluation of multivariate adaptive non-parametric reduced-order model for solving the inverse electrocardiography problem: a simulation study Onak, Onder Nazim; Serinağaoğlu Doğrusöz, Yeşim; Weber, Gerhard Wilhelm (Springer Science and Business Media LLC, 2019-05-01) In the inverse electrocardiography (ECG) problem, the goal is to reconstruct the heart's electrical activity from multichannel body surface potentials and a mathematical model of the torso. Over the years, researchers have employed various approaches to solve this ill-posed problem including regularization, optimization, and statistical estimation. It is still a topic of interest especially for researchers and clinicians whose goal is to adopt this technique in clinical applications. Among the wide range of...
A federated semantic metadata registry framework for enabling interoperability across clinical research and care domains Sınacı, Ali Anıl; Erturkmen, Gokce B. Laleci (Elsevier BV, 2013-10-01) In order to enable secondary use of Electronic Health Records (EHRs) by bridging the interoperability gap between clinical care and research domains, in this paper, a unified methodology and the supporting framework is introduced which brings together the power of metadata registries (MDR) and semantic web technologies. We introduce a federated semantic metadata registry framework by extending the ISO/IEC 11179 standard, and enable integration of data element registries through Linked Open Data (LOD) princi...
Examination of time-varying kinematic responses to support surface disturbances Gürses, Senih; Keshner, E. A. (Elsevier BV, 2011-01-01) To examine the evolution of inter-segmental coordination over-time, a previously developed multivariate model of postural coordination during quiet stance by Kuo et al. [1,2] has been extended. In the original model, postural coordination was treated as an eigenvalue-eigenvector problem between two segmental degrees of freedom represented by angular displacements of the trunk and shank. Strategies of postural coordination were then identified using the sign of the covariance between the two segments' angula...

Citation Formats

R. O. Doruk, “Development of a computer algorithm for feedback controlled electrical nerve fiber stimulation,” COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, pp. 132–144, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/63619.