A New Voltammetric Method for the Determination of Lercanidipine in Biological Samples

Date

2011-01-01

Author

Ozturk, Funda
Tasdemir, Ibrahim Hudai
Altunöz Erdoğan, Deniz
Erk, Nevin
Kilic, Esma

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

131
views

0
downloads

Electrochemical behavior and adsorption-diffusion properties of lercanidipine (LCN) on a glassy carbon electrode (GCE) were investigated in a mixture of ethanol-Britton Robinson buffer (BR) using voltammetric methods. From experimental results LCN was found to be reduced irreversibly via a single four-electron process controlled mainly by diffusion with some adsorption contribution at about -0.65 V (vs. Ag/AgCl reference electrode). Therefore, a new, accurate, rapid, selective and simple square-wave cathodic adsorptive stripping voltammetric (SWCAdSV) method could be developed for direct determination of LCN in pharmaceutical preparations, spiked human urine and spiked human serum samples without time-consuming steps prior to drug assay. The peak current of the reduction wave linearly changed with the concentration of LCN in the concentration range between 4.0 x 10(-8) molL(-1) and 7.6 x 10(-6) molL(-1) in two different regions where optimum preconcentration potential and optimum preconcentration time were applied as -0.20 V and 90 s, respectively. The limit of detection (LOD) and the limit of quantitation (LOQ) values were found to be 2 x 10(-8) molL(-1) (0.01 mgL(-1)) and 6 x 10(-8) molL(-1) (0.04 mgL(-1)), respectively. The method was applied to determine the content of LCN in commercial pharmaceutical preparation, spiked human serum and spiked human urine. The method was found to be highly accurate and precise, having a relative standard deviation of less than 10% in all applications.

Subject Keywords

Electrochemistry, Cyclic voltammetry, Square-wave adsorptive stripping voltammetry, Lercanidipine, Antihypertensive drug, Biological samples (spiked)

URI

https://hdl.handle.net/11511/54232

Journal

ACTA CHIMICA SLOVENICA

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

ELECTROCHEMICAL BEHAVIOR OF MOCLOBEMIDE AT MERCURY AND GLASSY CARBON ELECTRODES AND VOLTAMMETRIC METHODS FOR ITS DETERMINATION Altunöz Erdoğan, Deniz; Tasdemir, Ibrahim Hudai; Erk, Nevin; Kilic, Esma (2011-01-01) Electrochemical oxidation and reduction properties of Moclobemide (MCB) were investigated at glassy carbon electrode (GCE) and hanging mercury drop electrode (HMDE). Diffusion-adsorption behavior and some extra electrochemical parameters such as diffusion coefficient, number of transferred electrons and proton participated to its electrode mechanisms on both electrode and surface coverage coefficient were calculated from the results of cyclic voltammetry and square-wave voltammetry. Reversible catalytic hyd...
Electrochemical behaviour and electrochemical polymerization of fluoro-substituted anilines Cihaner, A; Önal, Ahmet Muhtar (2002-08-01) The electrochemical behaviour of three fluoro-substituted aniline monomers, 2-fluoroaniline (2FAN), 3-fluoroaniline (3FAN) and 4-fluoroaniline (4FAN), was investigated in aqueous acidic and organic media by means of cyclic voltammetry (CV) studies. Constant potential electrolysis (CPE) of the monomers in acetonitrile-water mixture (1: 1 by volume) using NaClO4 as supporting electrolyte yielded soluble polymers. The mechanism of electrochemical polymerization was investigated using in situ electron spin reso...
Spectroelectrochemical investigation of pentacarbonyl(pyrazine)metal(0) (metal = Cr, Mo, W) complexes of group 6 elements Yaman, SO; Nalbant Esentürk, Emren; Kayran, C; Önal, Ahmet Muhtar (2002-01-01) The electrochemical behaviour of pentacarbony l(pyrazine) metal (0) complexes of the group 6 elements was studied by cyclic voltammetry in dichloromethane-(n-Bu)(4)NBF4 solvent-electrolyte couple at -20 degreesC vs. Ag/Ag+ or SCE reference electrode. Constant potential electrolyses of the complexes were carried out at their first oxidation peak potentials and monitored in situ by UV-Vis spectrometry. Electrolysis of W(CO)(5)pz produces [W(CO)(5)pz](+) and a similar electrochemical mechanism is expected both...
Investigations on the electrochemical surface treatment of carbon fibers Bayramli, E; Toppare, Levent Kamil; Erinc, NK (2001-01-01) Desized polyacrylonitrile (PAN) based carbon fibers (CF) were chemically and electrochemically oxidized and reduced. CF surfaces were activated via cyclic voltammetry studies with anodic and cathodic scans. The changes in CF surfaces were studied by contact angle measurements. Lifshitz-van der Waals and acid-base components of single fibers were determined. In general, oxidation resulted in the formation of an acidic surface energy component and reduction gave rise to no change in the number of basic functi...
AN EXPERIMENTAL INVESTIGATION OF POLYVINYL-CHLORIDE) EMULSION POLYMERIZATION - EFFECT OF INITIATOR AND EMULSIFIER CONCENTRATIONS ON POLYMERIZATION KINETICS AND PRODUCT PARTICLE-SIZE Karakaş, Gürkan (Wiley, 1989-01-01) Effects of concentration changes in initiator species Na2SO3, (NH4)2S2O8 and CuSO4, and emulsifier, ammonium stearate, on poly(vinyl chloride) (PVC) emulsion polymerization kinetics and on product particle size were experimentally investigated. It was observed that to obtain industrially significant rates and overall conversions, not only an optimum concentration ratio of Na2SO3/(NH4)2S2O8/CuSO 4 must be used, but also the concentrations of these species must be above certain limits. Increasing the concentr...

Citation Formats

F. Ozturk, I. H. Tasdemir, D. Altunöz Erdoğan, N. Erk, and E. Kilic, “A New Voltammetric Method for the Determination of Lercanidipine in Biological Samples,” ACTA CHIMICA SLOVENICA, pp. 830–839, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/54232.