ELECTROCHEMICAL BEHAVIOR OF MOCLOBEMIDE AT MERCURY AND GLASSY CARBON ELECTRODES AND VOLTAMMETRIC METHODS FOR ITS DETERMINATION

Download

index.pdf

Date

2011-01-01

Author

Altunöz Erdoğan, Deniz
Tasdemir, Ibrahim Hudai
Erk, Nevin
Kilic, Esma

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

232
views

0
downloads

Electrochemical oxidation and reduction properties of Moclobemide (MCB) were investigated at glassy carbon electrode (GCE) and hanging mercury drop electrode (HMDE). Diffusion-adsorption behavior and some extra electrochemical parameters such as diffusion coefficient, number of transferred electrons and proton participated to its electrode mechanisms on both electrode and surface coverage coefficient were calculated from the results of cyclic voltammetry and square-wave voltammetry. Reversible catalytic hydrogen wave mechanism was proposed at HMDE and single two-electron/two-proton irreversible oxidation mechanism controlled by adsorption with some diffusion contribution at GCE was proposed. Experimental parameters were optimized to develop new, accurate, rapid, selective and simple voltammetric methods for direct determination of MCB in pharmaceutical dosage forms and spiked human serum samples without time-consuming steps prior to drug assay. In these methods, the lowest limit of detection (LLOD) was found to be 0.0235 mu M. Methods were successfully applied to determine the MCB content of commercial pharmaceutical preparations and spiked human urine. The methods were found to be highly accurate and precise.

Subject Keywords

Cyclic voltammetry, Electrochemistry, Electron transfer, Stripping voltammetry, Moclobemide

URI

https://hdl.handle.net/11511/33345

Journal

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

DOI

https://doi.org/10.1135/cccc2011041

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

A New Voltammetric Method for the Determination of Lercanidipine in Biological Samples Ozturk, Funda; Tasdemir, Ibrahim Hudai; Altunöz Erdoğan, Deniz; Erk, Nevin; Kilic, Esma (2011-01-01) Electrochemical behavior and adsorption-diffusion properties of lercanidipine (LCN) on a glassy carbon electrode (GCE) were investigated in a mixture of ethanol-Britton Robinson buffer (BR) using voltammetric methods. From experimental results LCN was found to be reduced irreversibly via a single four-electron process controlled mainly by diffusion with some adsorption contribution at about -0.65 V (vs. Ag/AgCl reference electrode). Therefore, a new, accurate, rapid, selective and simple square-wave cathodi...
Electrochemical behaviour and electrochemical polymerization of fluoro-substituted anilines Cihaner, A; Önal, Ahmet Muhtar (2002-08-01) The electrochemical behaviour of three fluoro-substituted aniline monomers, 2-fluoroaniline (2FAN), 3-fluoroaniline (3FAN) and 4-fluoroaniline (4FAN), was investigated in aqueous acidic and organic media by means of cyclic voltammetry (CV) studies. Constant potential electrolysis (CPE) of the monomers in acetonitrile-water mixture (1: 1 by volume) using NaClO4 as supporting electrolyte yielded soluble polymers. The mechanism of electrochemical polymerization was investigated using in situ electron spin reso...
Electrochemical polymerization of furan and 2-methylfuran Demirboga, B; Önal, Ahmet Muhtar (1999-02-26) Conductive polyfuran and poly(2-methyl)furan are prepared by controlled potential electrolysis in acetonitrile at room temperature. It is found that conductivity of polyfuran decreased by factor of 4 when methyl group is present in the a position. Temperature effect on the rate of polymerization of furan is studied by cyclic voltammetry technique and an increase in the initial rate of polymerization was observed with increasing temperature. Apparent activation energy of electrochemical polymerization of fur...
Electrochemical study of tricarbonyl(eta(6)-cyclooctatetraene)metal(0) complexes of the group 6 elements Yilmaz, GA; Önal, Ahmet Muhtar; Özkar, Saim (1998-08-01) Tricarbonyl(eta(6)-cyclooctatetraene)metal(0) complexes of the group 6 elements were prepared by using the procedures described in the literature with some minor modifications and identified by IR and NMR spectroscopy. Their electrochemical behavior was studied by using cyclic voltammetry in dichloromethane solution containing 0.1 M tetrabutylammonium tetrafluoroborate as supporting electrolyte. Their oxidation and reduction potentials were measured and discussed in terms of the frontier energy levels in co...
Electrochemical copolymerization and characterization of dianilines linked by polyether bridge with aniline TİRKEŞ, SEHA; Önal, Ahmet Muhtar (Springer Science and Business Media LLC, 2010-04-01) Copolymer of aniline and triethylene glycol bis(o-aminophenyl) ether was synthesized by constant potential electrolysis. Cyclic voltammogram of the copolymer films recorded in the monomer-free electrolytic solution revealed that the redox behavior of the films approaches to that of poly(triethylene glycol bis(o-aminophenyl) ether) with increasing amount of triethylene glycol bis(o-aminophenyl) in the feed ratio. Copolymerization was investigated by in situ recording the changes in the electronic absorption ...

Citation Formats

D. Altunöz Erdoğan, I. H. Tasdemir, N. Erk, and E. Kilic, “ELECTROCHEMICAL BEHAVIOR OF MOCLOBEMIDE AT MERCURY AND GLASSY CARBON ELECTRODES AND VOLTAMMETRIC METHODS FOR ITS DETERMINATION,” COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, pp. 423–442, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/33345.