ELECTROCHEMICAL BEHAVIOR OF MOCLOBEMIDE AT MERCURY AND GLASSY CARBON ELECTRODES AND VOLTAMMETRIC METHODS FOR ITS DETERMINATION

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2011-01-01

Author

Altunöz Erdoğan, Deniz
Tasdemir, Ibrahim Hudai
Erk, Nevin
Kilic, Esma

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Electrochemical oxidation and reduction properties of Moclobemide (MCB) were investigated at glassy carbon electrode (GCE) and hanging mercury drop electrode (HMDE). Diffusion-adsorption behavior and some extra electrochemical parameters such as diffusion coefficient, number of transferred electrons and proton participated to its electrode mechanisms on both electrode and surface coverage coefficient were calculated from the results of cyclic voltammetry and square-wave voltammetry. Reversible catalytic hydrogen wave mechanism was proposed at HMDE and single two-electron/two-proton irreversible oxidation mechanism controlled by adsorption with some diffusion contribution at GCE was proposed. Experimental parameters were optimized to develop new, accurate, rapid, selective and simple voltammetric methods for direct determination of MCB in pharmaceutical dosage forms and spiked human serum samples without time-consuming steps prior to drug assay. In these methods, the lowest limit of detection (LLOD) was found to be 0.0235 mu M. Methods were successfully applied to determine the MCB content of commercial pharmaceutical preparations and spiked human urine. The methods were found to be highly accurate and precise.

Subject Keywords

Cyclic voltammetry, Electrochemistry, Electron transfer, Stripping voltammetry, Moclobemide

URI

https://hdl.handle.net/11511/33345

Journal

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

DOI

https://doi.org/10.1135/cccc2011041

Collections

Department of Chemistry, Article

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Citation Formats

D. Altunöz Erdoğan, I. H. Tasdemir, N. Erk, and E. Kilic, “ELECTROCHEMICAL BEHAVIOR OF MOCLOBEMIDE AT MERCURY AND GLASSY CARBON ELECTRODES AND VOLTAMMETRIC METHODS FOR ITS DETERMINATION,” COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, pp. 423–442, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/33345.