Biodegradable hydroxyapatite - Polymer composites

The fracture of bone due to trauma or due to natural aging is one of the most frequent types of tissue failures. Treatment frequently requires the implantation of ct temporary or permanent prosthesis. The implanted materials may include the components of artificial joints, plates, and screws for fracture fixation. Typically, such implants are intended only to provide structural support or to serve as templates for bone re-growth. In general they are intended to remain in place for the life of the patient or to be removed in a second surgical procedure. This report provides a shout review of the synthetic reconstructive bone implants. Following this, the rationale ann basics of the biodegradable hydroxyapatite-polymer composite approach are described.


Biomechanics of porous ceramic implants used in long-bones segmental defect healing
Balçık, Cenk; Tokdemir, Turgut; Korkusuz, Feza; Department of Engineering Sciences (2002)
Reconstruction of bone in segmental defect is a challenging orthopedic application in which nonunion is seen due to loss of tissue and atrophic bonding inability. Calcium and phosphate based ceramics are the new generation of bone grafts to be used in large segmental defects as they show excellent biocompatibility, biodegradability and osteoconductivity. Ideal ceramic composition, configuration and material property compatible to cortical bone is yet to be determined. It is hypothesized that long-bones segm...
Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings
TAMAY, DİLARA GÖKSU; Gokyer, Seyda; Schmidt, Jurgen; Vladescu, Alina; HURİ, PINAR; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin (2022-01-12)
In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium-...
Etiology of senile osteoporosis - A hypothesis
Atik, O. Sahap; Uslu, M. Murad; Eksioglu, Fatih; Satana, Tolgay (Ovid Technologies (Wolters Kluwer Health), 2006-02-01)
Osteoporosis is a major health problem characterized by compromised bone strength predisposing patients to an increased risk of fracture. It may cause morbidity and mortality in elderly men and women. The etiologic factors that lead to senile osteoporosis still are unclear.
Mechanical design and analysis of a novel fixation device for human bone fractures
Yenigün, Çağrı; Tönük, Ergin; Oğuz, Erbil; Department of Biomedical Engineering (2016)
Fixation of bone fractures over a desired time period is one of the most important requirement for their healing processes. Fracture fixation devices are designed to satisfy particular requirements for different types of bone fractures. Conventional and locking plates, intramedullary rods and screws of trauma surgery, and polyaxial screws, connectors and rods of spinal surgery are the examples of contemporary implants for varying bones and their fractures. The mentioned fixation system is inspired from spin...
Biodegradable polymer - hydroxyapatite nanocomposites for bone plate applıcations
Aydın, Erkin; Hasırcı, Vasıf Nejat; Planell, Joseph A.; Department of Biotechnology (2010)
Long bone fractures are fixed with bone plates to restrain movement of bone fragments. Fracture site must experience some pressure for proper healing. Bone plates are mostly made up of metals having 5 - 10 times higher elastic modulus than bones and most of the load is carried by them, leading to stress shielding and a bony tissue with low mineral density and strength. To avoid these problems, biodegradable polymer-based composite plates were designed and tested in this study. Poly(L-lactide) and Poly(3-hyd...
Citation Formats
C. Durucan, “Biodegradable hydroxyapatite - Polymer composites,” ADVANCED ENGINEERING MATERIALS, pp. 227–231, 2001, Accessed: 00, 2020. [Online]. Available: