Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings

Date

2022-01-12

Author

TAMAY, DİLARA GÖKSU
Gokyer, Seyda
Schmidt, Jurgen
Vladescu, Alina
HURİ, PINAR
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

213
views

0
downloads

In orthopedic surgery, metals are preferred to support or treat damaged bones due to their high mechanical strength. However, the necessity for a second surgery for implant removal after healing creates problems. Therefore, biodegradable metals, especially magnesium (Mg), gained importance, although their extreme susceptibility to galvanic corrosion limits their applications. The focus of this study was to control the corrosion of Mg and enhance its biocompatibility. For this purpose, surfaces of magnesium-calcium (MgCa1) alloys were modified with calcium phosphate (CaP) or CaP doped with zinc (Zn) or gallium (Ga) via microarc oxidation. The effects of surface modifications on physical, chemical, and mechanical properties and corrosion resistance of the alloys were studied using surface profilometry, goniometry, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), nanoindentation, and electrochemical impedance spectroscopy (EIS). The coating thickness was about 5-8 mu m, with grain sizes of 43.1 nm for CaP coating and 28.2 and 58.1 nm for Zn- and Ga-doped coatings, respectively. According to EIS measurements, the capacitive response (Y-c) decreased from 11.29 to 8.72 and 0.15 Omega(-1) cm(-2) s(n) upon doping with Zn and Ga, respectively. The E-corr value, which was -1933 mV for CaP-coated samples, was found significantly electropositive at -275 mV for Ga-doped ones. All samples were cytocompatible according to indirect tests. In vitro culture with Saos-2 cells led to changes in the surface compositions of the alloys. The numbers of cells attached to the Zn-doped (2.6 x 10(4) cells/cm(2)) and Ga-doped (6.3 x 10(4) cells/cm(2)) coatings were higher than that on the surface of the undoped coating (1.0 x 10(3) cells/cm(2)). Decreased corrosivity and enhanced cell affinity of the modified MgCa alloys (CaP coated and Zn and Ga doped, with Ga-doped ones having the greatest positive effect) make them novel and promising candidates as biodegradable metallic implant materials for the treatment of bone damages and other orthopedic applications.

URI

https://hdl.handle.net/11511/96020

Journal

ACS APPLIED MATERIALS & INTERFACES

DOI

https://doi.org/10.1021/acsami.1c16307

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

Biodegradable hydroxyapatite - Polymer composites Durucan, Caner (2001-04-01) The fracture of bone due to trauma or due to natural aging is one of the most frequent types of tissue failures. Treatment frequently requires the implantation of ct temporary or permanent prosthesis. The implanted materials may include the components of artificial joints, plates, and screws for fracture fixation. Typically, such implants are intended only to provide structural support or to serve as templates for bone re-growth. In general they are intended to remain in place for the life of the patient or...
Etiology of senile osteoporosis - A hypothesis Atik, O. Sahap; Uslu, M. Murad; Eksioglu, Fatih; Satana, Tolgay (Ovid Technologies (Wolters Kluwer Health), 2006-02-01) Osteoporosis is a major health problem characterized by compromised bone strength predisposing patients to an increased risk of fracture. It may cause morbidity and mortality in elderly men and women. The etiologic factors that lead to senile osteoporosis still are unclear.
Improvement of bioactivity with dual bioceramic incorporation to nanofibrous PCL scaffolds Altunordu, Gercem; Tezcaner, Ayşen; Evis, Zafer; Keskin, Dilek (2023-03-01) Bone tissue injuries, diseases or related clinical interventions require bone tissue engineering (BTE) approaches for regeneration of large bone defects, especially for compromised situations. Most BTE applications in literature focused on composites of polymers with a single type of bioceramic. However, native bone matrix has various inorganic components. Accordingly, this study aimed to investigate the use of dual bioceramics in BTE scaffolds prepared by wet-electrospinning of Poly-caprolactone (PCL) and ...
Dip coating of calcium hydroxyapatite on Ti-6Al-4V substrates Mavis, B; Tas, AC (2000-04-01) Ti-6Al-4V alloy is the most commonly used metallic material in the manufacture of orthopedic implants. The main inorganic phase of human bone is calcium hydroxyapatite (Ca-10(PO4)(6)-(OH)(2), HA). To achieve better biocompatibility with bone, metal implants made of Ti-6Al-4V are often coated with bioceramics. Dip-coating techniques scarcely are used to apply HA onto metallic implants. New dipping-solution recipes to be used for HA coatings are described in this work. Scanning electron microscopy and X-ray d...
Graphene oxide reinforced doped dicalcium phosphate bone cements for bone tissue regenerations Motameni, Ali; Alshemary, Ammar Z.; Dalgic, Ali Deniz; Keskin, Dilek; Evis, Zafer (2022-09-01) Artificial bone cements have widespread applications in orthopedic and dental surgeries. Nevertheless, there is a need to develop novel materials for artificial bone cements due to limitations like short-service life, weak interaction and attachment with living hard tissue, and the inability to facilitate bone regeneration of calcified tissues rather than replacing them. In the present research, a novel combination of lanthanum (La3+) ions doped dicalcium phosphate (DCP) (La-DCP) and 1.5-3.5 wt.% of graphen...

Citation Formats

D. G. TAMAY et al., “Corrosion Resistance and Cytocompatibility of Magnesium-Calcium Alloys Modified with Zinc- or Gallium-Doped Calcium Phosphate Coatings,” ACS APPLIED MATERIALS & INTERFACES, vol. 14, no. 1, pp. 104–122, 2022, Accessed: 00, 2022. [Online]. Available: https://hdl.handle.net/11511/96020.